Most of McConnell's academic career was spent in the psychology department at the University of Michigan, where he was a professor from 1963 through his retirement in 1988. He was an unconventional scientist, setting up his own refereed journal, the Journal of Biological Psychology, which was published in tandem with the Worm Runner's Digest, a planarian-themed humor magazine. His paper Memory transfer through cannibalism in planarians, published in the Journal of Neuropsychiatry, reported that when planarians conditioned to respond to a stimulus were ground up and fed to other planarians, the recipients learned to respond to the stimulus faster than a control group did. McConnell believed that this was evidence of a chemical basis for memory, which he identified as memory RNA. Although well publicized, his findings were not completelyreproducible by other scientists and were therefore at the time completely discredited. McConnell's work has been referred to by a scientist who hypothesized that McConnell's results could be explained by RNA interference . McConnell originally published satirical articles alongside serious scientific articles in the Journal of Biological Psychology but received complaints that it was difficult if not impossible to tell which was which. He decided to publish the satirical Worm Runner's Digestupside down with its cover as the back of the Journal of Biological Psychology to make it clear which articles were satire. This, he said, created problems with librarians returning the Journal to the publisher with the complaint that it was improperly bound. He was amused by this. He spent many of his evening hours in the 1960s in informal rap sessions with students in their dorms. He was prone to making provocative statements, believed that memory was chemically based and that in the future humanity would be programmed by drugs. He once commented that he would rather be "a programmer than a programmee". McConnell was one of the targets of Theodore Kaczynski, the Unabomber. In 1985, he suffered a hearing loss when a bomb, disguised as a manuscript, was opened at his house by his research assistant Nicklaus Suino.
