Hoffman was born and is growing up in Atkinson, Nebraska. His parents are Andy and Bri Hoffman and he has two sisters, Ava and Reese. On April 22, 2011 Hoffman was having breakfast with his parents when he became unresponsive. He was rushed to the local hospital in Atkinson, Nebraska, where he had a grand mal seizure lasting 30 minutes. He was then flown to Children's Hospital & Medical Center in Omaha, Nebraska, due to the life-threatening seizure. He was subsequently diagnosed with a brain tumor. While at the hospital, Hoffman continued to have up to 10 to 12 seizures per day even though he was taking anticonvulsant medication. On May 20, 2011 he had surgery, but the neurosurgeon could only remove a small portion of the tumor. Subsequent pathology showed that it was a cancerous glioma, pediatric brain cancer. Hoffman's parents then consulted Boston Children's Hospital for a second opinion. Neurosurgeon Liliana Goumnerova told the Hoffmans that she could remove the golf-ball sized tumor. On October 10, 2011, Hoffman had a second surgery. Over 90% of the tumor was removed and the seizures stopped. Surgery was followed by another 60 weeks of chemotherapy. In October 2013, Hoffman's father reported that an MRI revealed that the remaining tumor was the same as in an MRI done in June, 2013, indicating that the cancerous tumor was not growing. As of April 2014, his cancer was still in remission.
Touchdown run
During the time between Hoffman's first and second surgeries, his father called Keith Zimmer who was the associate director of Life Skills at the University of Nebraska-LincolnAthletic Department. He wanted to get a picture of his son with his favorite Nebraska football player, Rex Burkhead. Burkhead agreed and met the family in September 2011. He had lunch with the Hoffman family, showed them Memorial Stadium, and decided he wanted to keep in touch with Hoffman. On Friday, October 7, 2011, Burkead called Hoffman before his second surgery to wish him well. The next day Nebraska played Ohio State in a game nationally televised by ABC, and ABC announcers mentioned Hoffman's story. At halftime of the game, Nebraska trailed Ohio State 20-6. At that time Burkhead thought about Hoffman and he said to his teammates "Jack's not giving up and we're not giving up." Nebraska ended up winning the game, 34-27, which was the largest comeback in Nebraska football history. In September 2012, Hoffman walked with the Nebraska players on to the field for their game against Wisconsin. In April 2013, as the spring football game neared, Jeff Jamrog had the idea of getting Hoffman into the spring game. He ran the idea by football coach Bo Pelini the night before the game and Pelini approved. Jamrog told the Hoffmans about their plan to get Jack into the game that night and the Hoffmans quickly made a uniform for him to wear the next day. During the game, the Hoffmans were on the sidelines with the team. As the fourth quarter began, the Red team had fourth down and one yard to go on their own 32 yard line. Pelini called timeout and sent Hoffman into the game wearing number 22. As the play began, Nebraska quarterbackTaylor Martinez initially guided Hoffman in the right direction and then he ran for a touchdown. When he reached the end zone, the players lifted him onto their shoulders in front of 60,174 people at Memorial Stadium. The story leading up to the touchdown run and the video of the run were covered extensively nationally and internationally. By April 16, 2013, a YouTube video of the touchdown run had been viewed over seven million times.
Team Jack
After Rex Burkhead met Hoffman, a bond began to grow between him and the Nebraska football team. The players decided to start an initiative to raise money for cancer research they called "Team Jack." Team Jack sold 30,000 T-shirts and collected $275,000 in donations, which they gave to the Dana Farber Cancer Institute in Boston, Massachusetts. The Hoffman family subsequently established the Team Jack Foundation, which has raised almost $1.5 million for pediatric brain cancer research.
Awards, celebrity, and influence
On April 29, 2013, the Hoffman family and Rex Burkhead met with President Barack Obama in the Oval Office for 15 minutes. Obama told Hoffman that he was proud of him and gave him a football. When asked about his meeting with the president, Hoffman replied "I thought it was awesome." In May, 2013, Upper Deck Company made a "Star Rookie" trading card for Hoffman. Upper Deck's sports marketing manager explained why they created the trading card: "Jack is the type of inspirational athlete who absolutely deserves an Upper Deck rookie card." The sale of the cards has brought in $50,000 for the Team Jack Foundation. After attending the May 16, 2014, 19th Annual Dick Vitale Gala, where Hoffman signed a trading card for Dick Vitale, the Sarasota Herald-Tribune wrote: "Yes, he may be an 8-year-old celebrity, but really, he’d much rather be a regular kid." Hoffman won an ESPY Award for Best Moment ESPY Award in 2013. Hoffman's touchdown run was listed fifth in The Best Emotional Moment in sports for 2013 by USA Today. Hoffman was also one of five nominees for Sportsman of the Year by Sports Illustrated in 2013. Senator Deb Fischer offered a resolution to the Senate that states that pediatric brain cancer is a leading cause of death. The resolution also singles out Hoffman's touchdown run for increasing awareness of pediatric brain cancer:
Cancer returns
On August 5, 2014, Hoffman found out that his tumor had grown since his April, 2014 MRI. His father reported that in April, there was a spot in his scan, but that they had hoped that it was nothing. Hoffman will likely undergo further chemotherapy or surgery. After consultation with Hoffman's medical team, in mid-August 2014, his parents decided to pursue a clinical trial in Boston involving a genetic therapy approach in part because the cancer has spread to the brain stem making surgery difficult. After the 13-month clinical trial, Hoffman has been off cancer treatment since 2015.
