Isovaleramide


Isovaleramide is an organic compound with the formula 2CHCH2CNH2. The amide derived from isovaleric acid, it is a colourless solid.

Occurrence and biological activity

Isovaleramide is a constituent of valerian root.
In humans, it acts as a mild anxiolytic at lower doses and as a mild sedative at higher dosages. Isovaleramide has been shown to be non-cytotoxic and does not act as a CNS stimulant. It inhibits the liver alcohol dehydrogenases and has a reported of greater than 400 mg/kg when administered intraperitoneally in mice.
It is a positive allosteric modulator of the GABAA receptor, similarly to isovaleric acid.