Blanco started his career with Colón in 2002. He suffered a serious knee injury in 20q04. Having lost his place on the first team, after his rehabilitation he was loaned out in January 2005 to Club Libertad of Paraguay, where he had the opportunity to participate at the Copa Libertadores 2005, scoring twice during his team's unsuccessful effort in Group 1. After his loan spell in Club Libertad, he returned in June 2005 to Argentina, to play on loan for Olimpo de Bahía Blanca, a Primera B Nacional team. During his stay there he managed to score 46 times in 90 games, helping his team win the Primera B Nacional and the promotion to Primera División and being the top scorer in both the Apertura2006 and the Clausura2007. In summer 2007, he rejoined Colón.
He did not stay with Colon for long; on 10 August 2007 Blanco joined AEK Athens on loan. He got his first appearance in an UEFA Cup match against Red Bull Salzburg on 20 September 2007. He then debuted in the Superleague Greece against Atromitos and scored twice leading AEK Athens to a 2–0 win. Blanco's first goal in a European competition occurred on 13 February 2007 against Getafe with a back flick in the 94th minute to end the game as a 1–1 draw. Blanco finished top scorer in the 2007–08 Superleague Greece having scored 19 goals in 28 games. His performances led AEK Athens to announce the activation of the clause in his contract on 28 April 2008. Blanco started his second season in AEK scoring the winning goal via a penalty against Panathinaikos in the year's first derby match. Blanco also stated to the press that he does not want to leave AEK and wants to be playing for many years in Greece. Blanco scored his first Greek Cup goal against Chaidari. Blanco finished top scorer in the 2008–09 Superleague Greece having scored 14 goals in 30 games. Blanco's third season at AEK wasn't as successful as the previous years as he scored only 13 goals all season,. In his fourth season he scored 15 goals in all competitions. His first goals came in the 5–1 win against Panthrakikos F.C. for the Greek Cup, in which Blanco scored his first hat-trick. He scored also game winner against arch rivals Olympiakos in the 90th minute. Blanco decided not to renew his contract with AEK and not to accept the proposal of AEK and he was released to a free agent. Blanco promised that if ever returned in Greece that would be only to wear AEK Athens' colours.
The 29-year-old cut short a spell in Europe with AEK to move to Mexican side San Luis last summer, but has quickly headed back to Europe. Blanco was highly rated back in 2007 when AEK snapped him up from Club Atletico Colon; the striker had enjoyed impressive spells on loan with Libertad and Olimpico. The striker will now hope to pick up his success in Europe with Polish outfit Legia Warsaw. On 24 February 2012, Blanco was signed by Polish club Legia Warsaw until 30 June 2012 with an option of extending to another season. Legia managed to win the Polish Cup of that season. He was released on 15 May 2012 as he did not fulfil the club's expectations, having only scored two goals in the Polish Cup.
After leaving Legia Warsaw, Blanco signed for TSV 1860 München, as well as his former AEK Athens' teammate Grigoris Makos. He didn't fulfill the expectations of the club, not finding the net in 13 caps for the 2. Bundesliga.
Return to South America
On February 2013, Blanco returned to his homeland, Argentina to join Lanús. He was given his favourite number, "18" On 16 June, Blanco scored twice against River Plate in a 5–1 victory. He scored five goals in 16 appearances for the 2013 Torneo Final and Lanús took the third place. On 17 August 2014 Blanco signed a two years' contract for Barcelona SC an Ecuadorian sports club based in Guayaquil. The total amount of transfer is estimated to €2.9 million. On 22 August 2016, he rejoined Colón. On 11 August 2017, he joined Atlético Tucumán.
Egaleo
In January 2020, he joined Greek club Egaleo in the Football League, who compete in the Greek third tier. Blanco previously played for Club Atlético Mitre in the Argentine second division where he scored three goals in 11 matches last season. He did not renew his contract with the Argentine club and decided to return to Greece at 37 years old.
Celebration
On 26 September 2007 in a match against Veria, after putting AEK Athens in front, Blanco revealed a Zorro mask from his sock and drew a big Z in the air celebrating the winning goal. He kept doing so from time to time though referees usually punished him with a yellow card. As a result, he gained the nickname "Zorro" by the fans.
Personal life
Blanco is of Egyptian descent. He is the oldest brother of Sebastián Blanco.
