Antonova studied under Boris Vipper at the Moscow University, graduating in 1945. Later that year she joined the staff of the Pushkin Museum, where she has worked ever since. In February 1961 Nikita Khrushchev put her in charge of the museum. Antonova witnessed as the entire collection of the Dresden Gallery arrived to the museum from Germany in 1945 and was removed from it ten years later. She opposed the return of the collection to Germany, claiming it was a just compensation for the damage inflicted on Russia's cultural heritage by the German invaders. The museum still holds Priam's Treasure, taken as a trophy by the Red Army after the Battle of Berlin. Antonova's interests revolve around Impressionist and Modern art. In 1948, the Pushkin Museum acquired considerable holdings of these works from the nationalized collections of Sergei Shchukin and Ivan Morozov. Antonova was also instrumental in establishing Svyatoslav Richter's December nights, an international music festival that has been held in the museum since 1981. Antonova had long supported the recreation of the State Museum of New Western Art, a museum created from the collections of Sergei Shchukin and Ivan Morozov, destroyed by Stalin in 1948. The collections of the museum were dispersed to the Pushkin and the Hermitage Museum. The Hermitage has been reluctant to let its collection go to the proposed museum and Antonova and the Hermitage director, Mikhail Piotrovsky publicly disagreed over the issue. The Russian Government proposed an online "virtual museum", which Antonova rejected. A spokesperson for Russian President Vladimir Putin said that "the chances of creating such a museum fall significantly" after Piotrovsky's disapproval. Antonova later said people who were against the recreation of the museum were "adhering to a decree of Stalin." Shortly after the controversy, Antonova was fired and replaced by Marina Loshak. Antonova oversaw art collections which were taken by Soviet Union from Germany after World War II. She first denied that such collections exist, and when it was apparent that they exist started publicly stating that the collections were taken to the Soviet Union legally and should be exempt from the restitution.
Personal life
She was married to Russian art historian Evsey Rotenberg, who died 2011.