In 2002, Chief Ekweremadu was appointed Secretary to the Enugu State Government, before then he was Chairman of Aninri in 1997 and won the Best Local Government Chairman Award in Enugu State at the time. He was appointed the Chief of Staff to the Enugu State Government House.
Senatorial career
On April 12, 2003 he was elected to the Nigerian Senate. In September 2003, as Vice Chairman of the senate committee on Information, Chief Ekweremadu stated that the senate would make a serious investigation into allegations of bribery leveled by Federal Capital Territory minister Mallam Nasir el-Rufai. Relations between Nasir El-Rufai and the senate continued to be hostile, and El-Rufai was eventually charged with corruption in 2008. In 2005, Ike Ekweremadu was beaten in the race for President of the Senate of Nigeria by Senator Kenechukwu Nnamani. In July 2006, as spokesperson for the Southern Senators’ Forum, Ekweremadu denied charges that they had made an agreement to return power to the North in the 2007 elections. In September 2006, President Olusegun Obasanjo asked the Senate to review a report by the Economic and Financial Crimes Commission that laid charges of fraud against Vice-President Atiku Abubakar. Ike Ekweremadu promised to establish a committee of inquiry whose report would be submitted to the Senate, although he noted that impeachment would be difficult since it would require a 2/3 majority. Ekweremadu was returned in the 29 April 2007 Nigerian National Assembly election, and elected to the position of deputy senate president. He was given the job of handing out committee chairmanship positions allocated to the southeast zone, making decisions that were unpopular with leaders such as Senator Chris Anyanwu, who failed to get the positions they wanted. In July 2007, Ekweremadu was instrumental in defusing objections to the controversial nomination of Ojo Maduekwe to a ministerial position. When President Umaru Yar'Adua’s Principal Private Secretary, David Edevbie, was indicted in September 2009 in a British court for corruption and money laundering, Ekweremadu refused to take a position, stating that he did not know the facts. In September 2009, Ekweremadu was named co-chairman of a committee to conduct the primary elections for the Peoples Democratic Party’s governorship candidate for Anambra State.
Senatorial Election 2011
Ekweremadu was reelected as Senator for Enugu West in the April 2011 elections, receiving 112,806 votes. The closest runner-up was the candidate of the Peoples for Democratic Change, Jackson Ezeoffor, who got 7,522 votes.
Senatorial Election 2019
On February 23, 2019, Ekweremadu was re-elected as senator representing the Enugu West senatorial district For the Fifth Consecutive time having polled 86,088 votes to defeat his closest rival, Mrs Juliet Ibekaku-Nwagwu of the All Progressives Congress who polled 15,187 votes. On June 11, 2019, Ekweremadu lost his bid to become Deputy Senate President of the Nigerian 9th Senate. Ekweremadu contested against Ovie Omo-Agege who scored 68 votes to emerge Winner.. In the early hours of Tuesday, he returned his officials cars. Ekweremadu has indicated he will retire from the Nigerian Senate by not running for office in 2023.
ECOWAS
In September 2009, he was appointed to lead the Economic Community of West African Statesad hoc committee to work for the return of constitutional order in the Niger Republic. He was elected First Deputy Speaker of the ECOWAS Parliament and emerged the Speaker of the regional parliament in August 2011.
On August 17, 2019, while attending the Second Annual Cultural Festival and Convention organized by Ndi-Igbo Germany in Nuremberg, Ekweremadu became the victim of a violent attack when members of the Indigenous People of Biafra IPOB stormed the venue of the event and began to question Ekweremadu about the killings of Igbos when the Nigerian army staged the and . They also questioned Ekweremadu about his purported role in the proscription of IPOB in Nigeria. The situation soon degenerated to the extent that Ekweremadu was physically dragged out of the venue, assaulted and pelted with eggs. He would later announce that he got away from the venue without any injuries. The leader of IPOB, Nnamdi Kanu would later issue a statement on the attack on Ekweremadu calling it a "polite warning" while at the same time warning other Igbo governors of a possible similar treatment.
