Hyperproinsulinemia
Hyperproinsulinemia is a disease where insulin is not sufficiently processed before secretion and immature forms of insulin make up the majority of circulating insulin immunoreactivity in both fasting and glucose-stimulated conditions. The term is composed of hyper - high, proinsulin - immature insulin molecule, and -emia - blood condition.
Hyperproinsulinemia is more frequent in type 2 diabetes. It has been attributed to either a direct β-cells defect or an indirect effect of cell dysregulation under sustained elevated blood glucose.
Some alleles of insulin can cause hyperproinsulinemia ]. For a more detailed descriptions of the insulin gene variations leading to hyperproinsulinemia see NCBI's
