After years of unprecedented success in the beverage industry, the Akhtar brothers entered the sugar industry and later expanded into production of its downstream products such as ethanol and carbon dioxide. Today, Tandlianwala Sugar Mills is the second largest publicly listed producer of sugar and its allied products on the Pakistan Stock Exchange in terms of revenue, market capitalization, production, and capacity while it is also the largest exporter of ethanol in the country, comprising 17% of Pakistan's total ethanol exports. The group includes three sugar mills in Tandlianwala, Muzaffargarh, and Dera Ismail Khan with a combined crushing capacity of 48,000 Tons of Cane per day ; two ethanol distilleries in Tandlianwala and Muzaffargarh with production capacity of 255,000 liters per day, and a Carbon Dioxide Recovery plant with capacity of 48 Tons Per Day.
In 2002 when PML was forming its government, Humayun Akhtar was one of the candidates considered for the post of Prime Minister. However, President Musharraf and the PML-Q eventually decided to choose the Prime Minister from one of the smaller provinces and hence gave the honor to Zafarullah Khan Jamali of Balochistan. By early 2004, it was clear that Jamali had fallen out of favor with PresidentMusharraf and his own party members. Jamali did not support Musharraf's decision to keep on his uniform amongst other things while Musharraf was fed up of Jamali's incompetence and poor governance. By May 2004, the party decided to sack Jamali and in his place a number of potential candidates were listed. After many high level consultations between the President and his close political and military aides, it was decided that Humayun was the best choice to lead the nation. Although Humayun had strong backing of the Pakistan Army and the ISI as many of the top generals had served under his father who led these institutions in the 1980s, his own party leaders the Chaudhrys of Gujrat proved to be the last hurdle in his nomination as they fought tooth and nail to ensure that he does not become the next Prime Minister. Party President Chaudhry Shujaat went to the extent of asking Musharraf to delay the announcement of the new Prime Minister by three weeks till the budget session concludes. Many political analysts believe that the main reason behind the delay was to postpone Humayun's candidacy as the Chaudhry's felt that he had intentions of hijacking the party from them and as a result threatening Pervaiz Elahi's own political ambitions of eventually becoming Prime Minister after the next election. Eventually Musharraf adhered to the pressure and the only other viable option for Musharraf was Finance MinisterShaukat Aziz who was a Senator, not a Member of Parliament. Eventually, Chaudhry Shujaat Hussain was made interim Prime Minister for two months and it was decided that Shaukat Aziz would contest an election for the national assembly via by-election. Shortly after contesting and winning the by-election, Shaukat Aziz replaced Chaudhry Shujaat as Prime Minister.
Alliance with PML-N (2012–2013)
In May 2012 the Likeminded Group formed an alliance with the PML in a bid to unite all Muslim League factions under the leadership of Nawaz Sharif, with the aim of defeating the PTI and the ruling coalition of PPP and PML in the upcoming general elections. According to the seat adjustment formula that would accommodate several leaders of the Likeminded Group, Humayun was to be awarded a PML ticket from NA-124Lahore instead of NA-125 while his brother Haroon Akhtar was to be awarded a PML senate seat in the 2015 senate elections. However, days before the election tickets were finalized, PML violated the agreement it signed in 2012 and Humayun did not receive a PML ticket from either of the two constituencies although his brother Haroon was accommodated in June 2015 as a Special Assistant to the Prime Minister on Revenue and was elected as a Senator on a PML ticket in the 2018 Senate Election. While Humayun has been out of the public eye over the past five years, he has been spearheading new joint ventures, mergers and acquisitions for his family businesses.
In July 2018, Humayun Akhtar joined Pakistan Tehreek-e-Insaf. Having served as a Member of the National Assembly several times from all of the areas comprising NA-131, he led PTI Chairman Imran Khan's campaign in the constituency and played an integral role in helping him defeat Khawaja Saad Rafique by a narrow margin of over 600 votes. After Imran Khan decided to keep his MNA seat from Mianwali, Humayun Akhtar was declared PTI's candidate for the by-election from NA-131.