In 1495, he fought in Italy on behalf of king Charles VIII of France,, disputing Naples to the Spaniards getting then under the service of Cesare Borgia,. In 1496, he fought the French in Catalonia and Rosillon.
Service with the Spanish
Under Ferdinand II of Aragon he fought against Berber privateers in Italian waters, being promoted to Viceroy of Sicily in 1509 keeping such position till 1517. In 1513, he helped the Count of Oliveto, Pedro Navarro, attack the port of Tripoli providing galleys from Sicily. In 1522, as a general for Charles V, Holy Roman Emperor, he besieges the battlements of Tournai. In 1524, with 16 galleys, he attacked and took the ramparts of Toulon, Hières and Frejus, but was defeated and captured by Andrea Doria at the mouth of the river Var. He was liberated in 1526 by the Treaty of Madrid. Under the terms of this Treaty, Moncada was exchanged for Montmorency. In June 1526, Moncada was sent by Emperor Charles V, as an ambassador to Pope Clement VII in Rome. Moncada carried a message to the pope that should he ally with the French in the War of the League of Cambrai that Charles V would seek to turn the city-state of Siena in northern Italy against the Papal States and would also use his influence with the Colonna family to also turn this important Italian family against Pope Clement VII. Pope Clement recognized the potency of these two threats and as the French marched into Lombardy, Pope Clement withdrew all his forces back to Rome.
He took command of the armies to take Lombardy and then marched to Rome. In May 1527, Moncada's Imperial troops sacked Rome. Ultimately, Moncada aided Clement VII, when the latter finally became a supporter of the emperor Charles V. In September 1527, Charles de Lannoy, the Viceroy of Naples died and Moncada was appointed in his place. In 1528, in the harbor of Naples, Moncada was blockaded by the French fleet under the command of the Genoese mercenary captain Filippino Doria. In the main naval battle of the whole of the Italian wars, Moncada tried to break out of the blockade that surrounded Naples. All of the ships of Moncada's fleet were sunk or captured and Moncada, himself was killed in the battle.
Some references
Mallett, Michael and Shaw, Christine, The Italian Wars: 1494-1559.