The series was created by Bob Lowry and features Hank Azaria as Dr. Craig "Huff" Huffstodt, a psychiatrist whose life changes abruptly when a 15-year-old client commits suicide in his office. The series follows Huff, his family, and his friend Russell Tupper, played by Oliver Platt, as they navigate life. The first season was broadcast on Showtime between November 7, 2004 and January 30, 2005. The second season premiered on April 2, 2006 and ended on June 25, 2006. Two days before the finale, Showtime announced that the show would not be picked up for a third season, and several plotlines, including the resolution of pending criminal charges against Russell Tupper and the possibility of reconciliation between Huff and Beth were left unresolved. The two-hour pilot episode was filmed in Vancouver, British Columbia. Later, production for Huff was moved to Delfino Stages in Los Angeles, California.
Hank Azaria as Dr. Craig "Huff" Huffstodt: a Los Angeles psychiatrist whose life is sent reeling when a tragedy occurs in his office. An eternal caretaker who thinks he can save people, Huff learns very brutally that he can't save everyone. He deals with the functionally insane all day, and when he comes home, he's faced with the daily insanities of family life.
Paget Brewster as Beth Huffstodt: Huff's loving yet capricious wife. She helps Huff avoid meltdowns, while providing welcome, wifely support and amenities.
Oliver Platt as Russell Tupper: Huff's lawyer, longtime friend and former running buddy from their single days. Although a source of questionable ethics and morality, he still gets it done with a sense of humor and comes through for Huff.
Blythe Danner as Isabelle "Izzy" Huffstodt: Huff's mother who has lived in the apartment above the garage since the breakup of her marriage. Izzy is tough and manipulative but also funny and irreverent.
Anton Yelchin as Byrd Huffstodt: Huff and Beth's 14-year-old son. He is a loving child who is concerned with his father's well being and to what's going on in the family. He's a very bright teenager.
Andy Comeau as Theodore "Teddy" Huffstodt: Huff's younger brother. Literally and figuratively locked away in a private mental institution, Teddy's mental illness brings clarity of thought for Huff during his visits.
Kimberly Brooks as Paula Dellahouse: Huff's office manager who protects him as much as she provokes him. She has been with Huff for a long time and knows him and his family very well.
Liza Lapira as Maggie Del Rosario: Russell's utterly devoted yet pull-no-punches assistant. She cares for him, covers for him and curses him, but it’s all in a day’s work for her as she knows she’s probably the only woman Russell has ever allowed himself to truly depend on.
Faith Prince as Kelly Knippers: a television sales rep whom Russell meets and woos while shopping for a flat screen. A wild night of partying and debauchery results in a pregnancy that changes both their lives.
