Dr. Yu worked as a Research Scientist in the Department of Microbiology and Immunology at the University of Michigan from 1994-1995, before joining the Immunology Program at the Moffitt Cancer Center in Tampa, Florida. She remained there until 2005, when she became Professor and Associate Chair of the Department of Cancer Immunotherapeutics & Tumor Immunology at the Beckman Research Institute of City of Hope in Duarte, California. In 2013, she became the inaugural Billy and Audrey L. Wilder Professor in Tumor Immunotherapy.
Research
Dr. Yu and her team were the first to identify as a critical regulator in processes influencing tumor [cell growth and survival. They examined activation of the STAT3 protein, and determined that it helps to create an environment supportive of the tumor cell, protecting it from nearby immune cells. By examining and understanding STAT3's role in tumor angiogenesis and immune evasion, they have also identified a possible molecular target for cancer therapy. Stat3 siRNA is used to disable STAT3 production, while CpG binds to the tumor cells and stimulates immune cells. In this way, CpG-Stat3 siRNA can turn off the defense mechanism of cancerous cells and prompt the immune system to attack them. Using mice as an animal model, Yu is studying the treatment of glioblastoma multiforme and B-cell lymphoma, particularly aggressive tumors that are resistant to standard forms of treatment. trials with human patients were being planned. Internationally known, Dr. Hua Yu has collaborated with Dr. Thomas Blankenstein at the Max Delbrück Center for Molecular Medicine in Germany and with Dr. Jie Liu at Fudan University, China. Technologies developed in her laboratory and that of Dr. Andreas Herrmann at City of Hope are being used by a newly formed company, LA Cell, Inc., which hopes to develop cell-penetrating antibody therapies. Preliminary evidence also suggests that Stat3 may be linked to diabetes.
Awards
In 2014, Dr. Yu received the Humboldt Research Award of the Alexander von Humboldt Foundation, granted to "academics, whose fundamental discoveries, new theories, or insights have had a significant impact on their own discipline and who are expected to continue producing cutting-edge achievements in the future."
