After graduating, Ho joined a Chinese shipping firm in Haiphong as a clerk and later worked as a translator at the Registrar-General's department. He joined a legal firm called Denneys & Mossop in 1882 as an interpreter and worked at the firm for three years. In 1891, he was appointed assistant compradore to the Jardine, Matheson & Co. under his elder brother Robert Hotung who was the chief compradore. He succeeded his brother as the chief compradore of the firm in 1900 and his younger half brotherHo Kom-tong became his assistant. His son, Ho Leung, succeeded his father to become the chief compradore of the Jardine, Matheson & Co. after his retirement. He was appointed many public offices as the leader of the Chinese community. He was appointed Justice of the Peace in 1892 and was appointed to the Legislative Council of Hong Kong in 1917 as one of the representatives of the Chinese community on retirement of Wei Yuk and served until 1921. In 1926, he was appointed to the Board which advised the government upon the distribution of the Trade Loan. He was also member of the District Watchmen's Committee, member of the Chinese Permanent Cemetery Committee, the Chinese Public Dispensaries Committee, advisory committee of the Tung Wah Hospital and Po Leung Kuk, the two most prominent charitable organisations in the colony. He was also the managing director of the local newspaper, Hongkong Telegraph. With Lau Chu-pak, they founded the Chinese General Chamber of Commerce in 1900. He served as vice-president of the Ellis Kadoorie Chinese School Society and member of the Court of the University of Hong Kong. he was also the founder of the annual scholarship for students at the Queen's College and the University of Hong Kong. His donation to the University of Hong Kong also became the foundation of the School of Physiology.
Death
Ho suffered from a relapse on 29 August 1926 and died in the afternoon.
Family
Ho Fook's father was a man of Jewish Dutch ancestry named Charles Henri Maurice Bosman and his mother was Madame Sze, a local woman of Bao'an heritage. His brothers Sir Robert Hotung and half brother Ho Kom-tong were also prominent social figures in Hong Kong. Ho Kom-tong's daughter Grace Ho was the mother ofBruce Lee. Ho Fook had thirteen sons and five of them survived when Ho Fook died. All of them were educated in England and three of whom worked as compradores for various foreign companies, Ho Leung was the chief compradore of the Jardine, Matheson & Co. after his father, Ho Iu was the compradore of the Mercantile Bank of India, London and China, and Ho Ki was the compradore of E.D. Sassoon & Co.. Ho Wing, another son of him who was adopted by Robert Hotung was also the compradore of the Hongkong and Shanghai Banking Corporation. There were also Ho Kwong and S. C. Ho in which the latter was member of the Sanitary Board. Ho Fook had also five daughters. One of Ho Fook's grandsons, Stanley Ho, was a casino and shipping magnate. Ho Fook lived at No. 10, Caine Road.
