List of highways numbered 250

• Arkansas Highway 250
• California State Route 250
• Farm to Market Road 250
• Georgia State Route 250
• Hawaii Route 250
• Illinois Route 250
• Indiana State Road 250
• Japan National Route 250
• Kentucky Route 250
• Manitoba Provincial Road 250
• Minnesota State Highway 250
• Montana Secondary Highway 250
• National Route 250 (Costa Rica)
• Nebraska Highway 250
• New Mexico State Road 250
• New York State Route 250
• Oregon Route 250
• Pennsylvania Route 250
• Prince Edward Island Route 250
• Puerto Rico Highway 250
• Tennessee State Route 250
• Texas State Highway 250
• Texas State Highway Loop 250
• U.S. Route 250
• Utah State Route 250