Reisler was a researcher at the Soreq Nuclear Research Center. In 1977 Reisler joined University of Southern California as a research associate with Curt Wittig, before being appointed Associate Professor in 1987. She was a member of the Centre for the Study of Fast Transient Processes, which was supported by the United States Army Research Laboratory. Reisler and Wittig worked on gas-surface and solid-state interactions. The first paper she published whilst at USC was included in James T. Yardley's book on energy transfer. During her tenure at USC, Reisler has worked in the Department of Electrical Engineering, Physics and Chemistry. She was made a full Professor at the University of Southern California in 1991. In his biography, Wittig described Reisler as "one of the most important faculty members of the College of Letters, Arts, and Sciences, if not the entire University". She is interested in the molecular mechanisms of chemical reactions. Resiler has looked at molecular transport and guest-host interactions in thin films. Her group at USC have evaluated vibrational pre-dissociation dynamics of hydrogen- bonded dimers and large clusters. She also works on the reactions of diradicals and amorphous solid water. In particular, she has studied cholomethyl radicals, hydroxyl radicals and NO dimers.
Academic service and advocacy
In 2000 there were only three women members of faculty across the USC Viterbi School of Engineering. Reisler founded the Women In Science and Engineering program at the University of Southern California. The program was launched with an anonymous $20 million donation, and continues to receive a $1 million per year endowment. She advocated for more comprehensive support for scientists with families. It has since provided fellowships and childcare support for students and postdocs. She created a networking group that meets once a month to share information and resources. She was appointed the Lloyd Armstrong Jr. Chair in Science and Engineering, which looks to advance the careers of women scientists. She is involved with mentorship of early career scientists. Her commitment to mentoring has been recognised by University of Southern California, who launched a mentorship award in her honour. She was honoured by Johns Hopkins University and nominated into their Society of Scholars in 2018.
