Resource was first commissioned in July 1778 under the command of Captain Patrick Fotheringham. On 19 April 1781 Resource recaptured the 20-gun post ship, which the French frigate Andromaque had captured on 4 September 1780. Resource had reached Cape Blaise by noon and at 2pm spotted a strange sail. By 4:30 Resource was close enough that both vessels began to exchange fire. After an hour and a half, the French vessel struck. She turned out to be Unicorn, and armed with twenty 9-pounder guns and eight 12-pounder carronades. She had a crew of 181 men under the command of Chevalier de St. Ture. In the engagement, Resource lost 15 men killed and 30 wounded; Unicorn lost eight men killed and 30 wounded, four of whom died later. Ten crew members were drowned in October 1799 when the ship's boat foundered in The Downs while returning to Resource after a journey to the shore. The dead included the captain of marines and the ship's purser. Because Resource served in the navy's Egyptian campaign, her officers and crew qualified for the clasp "Egypt" to the Naval General Service Medal that the Admiralty authorised in 1850 for all surviving claimants. With the resumption of war with France in 1803 Britain feared an invasion from France. Around 24 September 1803 the Admiralty decided to bring Unite,,,,,,, Retribution,, and Resource, out of ordinary and to sail them under jury rig to Long Reach to rearm. They were then to proceed to the Lower Hope, to be moored across the River for the protection of the Thames. Trinity House would be responsible for manning them. Between September and October 1803 Resource was at Deptford being refitted for Trinity House. In May 1805 Resource was still at Lower Hopein Ordinary, serving as a floating battery. On 17 April 1806 Resource was renamed Enterprise and assigned to service off the Tower of London.
Fate
The "Principal Officers and Commissioners of His Majesty's Navy" offered "Enterprise, of 28 guns and 603 tons", "lying at Deptford" for sale on 28 August 1816. She was sold on that day for £1,420.