HLA-B75


HLA-B75 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.
B75 is one of many s of the, B15. B75 is associated with a severe drug-induced skin condition in ethnic East Asians.

Serotype

Alleles

Diseases

HLA-B*1502 is associated with Carbamazepine and phenytoin induced Stevens–Johnson syndrome in Chinese and Thai. One study showed a 100% association between B*1502 and the drug induced skin disorder in Chinese. In Europe the B*1502 positive patients are only found in this syndrome of persons of East Asian descent, however B58 confers susceptibility to both groups but to a lesser degree and is sensitive to allopurinol.