HBE1


Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene.

Function

The epsilon globin gene is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilongamma-Ggamma-Adeltabeta - 3'.