Born in São Paulo, Gustavo Henrique moved to Salvador, Bahia at early age. He started his career at Vitória's youth setup, before moving back to his home state in 2007, after joining Santos.
Santos
Gustavo Henrique and made his first team – and Série A – debut on 17 June 2012, in a 0–1 away loss against Flamengo. He scored his first goal on 24 July of the following year, in a 2–0 away win against CRAC for the season'sCopa do Brasil. In mid-September 2013, Gustavo Henrique replaced Durval in the starting eleven, after the latter was deemed surplus to requirements. He scored his first league goal on 27 October, in a 1–1 away draw against Corinthians. Roughly a month later he scored his second, in a 2–2 away draw against Vasco da Gama. In late February 2014, Gustavo Henrique suffered a knee injury, being sidelined for six months. He returned to action in October, but was only selected on the bench in the remainder of the season. Gustavo Henrique played his first match after his injury on 1 February 2015, starting in a 3–0 home win against Ituano. In August, after the arrival of new manager Dorival Júnior, he was again first-choice after overtaking new signing Werley. On 29 February 2016, Gustavo Henrique renewed his contract until January 2020. He became an undisputed starter during the campaign, and on 12 June completed his 100th game for the club by starting in a 2–0 away win against Santa Cruz. In September, however, he suffered another knee injury, being sidelined for another six months. Gustavo Henrique returned to action on 14 August 2017, starting in a 0–0 home draw against Fluminense. On 10 September, in a 2–0 home win against Corinthians, he suffered another knee injury and was sidelined for the remainder of the year. Gustavo Henrique made his Copa Libertadores debut on 5 April 2018, replacing Renato late into a 1–0 away win against Estudiantes.
Flamengo
In December 2019, Gustavo Henrique agreed to a pre-contract deal with Flamengo, effective as of the following 1 February. On 3 January2020, however, he was announced by the club after agreeing to a four-year deal.
