Aguirre Beltrán was the son of a medical doctor in Veracruz state and he continued himself in medical studies, attending the National University and earning a B.S. in 1927 and his M.D. in 1931. He returned to his home state, and practiced medicine in the town of Huatusco for ten years. In his early years as a medical doctor, he became interested in local history and published a book on agrarian struggle during the colonial era. In 1942 he met Columbia University-trained anthropologist Manuel Gamio, who suggested that Aguirre Beltrán study blacks in Mexico, resulting in his landmark study, La población negra de México, 1519-1810: Estudio etnohistórico. He left the practice of medicine in favor of becoming an anthropologist, although he pursued topics on medical anthropology. He served in various government positions, including as head of the Sanitary Unit of Huatusco. He was appointed head of the Department of Demography in the Department of the Interior in the Manuel Avila Camacho and Miguel Alemán administrations. He director of Indigenous Affairs in the Secretariat of Public Education, a researcher for the National Indigenous Institute , coordinator of INI's Tzeltal-Tzotzil region, and subdirector of INI. He returned to Veracruz and became rector of the Universidad Veracruzana. Under the administration of Luis Echeverría he was sub-secretary of the Department of Culture and Continuing Education, creating a publication series disseminating research on indigenous communities.
Works
El señorío de Cuauhtocho: Luchas agrarias en México durante el virreinato 1940.
La población negra de México, 1519-1810: Estudio etnohistórico. Mexico City 1946.
Formas de gobierno indígena. Mexico City 1953.
Problemas de salud en la situación intecultural 1953
Problemas de la población indígena de la cuenca del Tepalcatepec 1953.
Cuijila: Esbozo etnográfico de un pueblo 1957.
Medicina y mágica: El proceso de aculturación Mexico City 1963.
Regiones de refugio: El desarrollo de la comunidad y el proceso dominical en mestizoamérica. Mexico City 1967., Society of Applied Anthropology 1979.
Teoría y práctica de la educación indígena 1973
Obra polémica 1976.
Lenguas vernáculas: Su uso y deuso en la enseñanza, la experiencia de México 1983.
Zongólica: Encuentro de dioses y santos patronos 1986.
Crítica antropólica: Contribuciones al estudio del pensamiento de México 1990.
Obra antropológica Mexico City 1989-1995. Mexico City, Fundo de Cultura Económica.