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Golexanolone
Golexanolone
, also known by the
developmental
code name
GR-3027
, is a
neurosteroid
medication
which is
under development
for the
treatment
of
hypersomnia
and
hepatic encephalopathy
. It
acts
as a
negative allosteric modulator
of the
GABA
A
receptor
. The medication selectively antagonizes the stimulatory
actions
of
inhibitory
neurosteroids
like
allopregnanolone
and
tetrahydrodeoxycorticosterone
at the GABA
A
receptor, while not
affecting
the
activation
of the GABA
A
receptor by
γ-aminobutyric acid
.
