Amedore was born and raised in Schenectady County. As of 2011, he was Vice President of Amedore Homes, a business founded in 1974 by his father, George Amedore, Sr. In 2007, Amedore and his family business were "featured on ABC-TV's "Extreme Makeover -- Home Edition" when they "brought together dozens of subcontractors to build a 3,600-square-foot home at no cost" for a local family.
Amedore was first elected to the State Assembly on July 31, 2007 in a special election to fill a vacancy created by Paul Tonko's appointment by Governor Eliot Spitzer to lead the New York State Energy Research and Development Authority. Amedore ran against Democrat Ed Kosiur, a Schenectady County legislator. Amedore was re-elected to the Assembly in 2008 and 2010, defeating Democrats Mark Blanchfield and Angelo Santabarbara, respectively.
Rather than seeking re-election to the Assembly in 2012, Amedore chose to run for the New York State Senate in District 46. The district was a newly drawn district stretching from Montgomery County to Ulster County. Although there were more registered Democrats than Republicans in the district, Amedore was initially favored because he had represented the entire northern portion of the district for five years. Amedore trailed Democrat Cecilia Tkaczyk on election night, but legal action by Amedore forced a judge to monitor the counting of 6,000 provisional and absentee ballots. The judge threw out 450 votes, enough to give Amedore a 37-vote lead. Amedore was certified as the winner and filed his oath of office in January. However, Tkaczyk appealed, contending that since the ballots were primarily in Democratic-leaning areas, she could potentially win if they were all counted. Eventually, a court ordered 99 ballots in Ulster, Albany, and Greene counties opened. Tkaczyk picked up enough votes in the opened ballots to take an 18-vote lead. Amedore conceded the race on January 18. At the time, according to the Albany Times Union, Amedore was the shortest-tenured senator in the modern history of that chamber. Amedore ran against then-incumbent Senator Tkaczyk in the 2014 elections and won. He was re-elected in 2016, defeating challenger Sara Niccoli by a wide margin. He again won reelection in 2018. Prior to Democrats taking the majority, Amedore served as Chair of the Senate Alcoholism and Drug Abuse Committee and the Senate Technology and Innovation Task Force. He also served as Co-Chair of the Heroin Task Force. Amedore received the 2019 Oil Slick Award from Environmental Advocates for what they deemed to be his consistently-poor environmental record. In November 2019, Amedore announced that he would not seek re-election to the Senate in 2020.
Personal
Amedore resides in Rotterdam, New York with his wife Joelle. The Amedores have three children: George, Anthony, and Bria. Amedore is a Christian. As of 2011, Amedore was a member of Calvary Tabernacle Assembly of God Church in Schenectady.
Election results
July 2007 special election, NYS Assembly, 105th AD
