In 1964, the Democrats in Illinois' 19th Congressional District had no candidate in the primary for U.S. representative. Friends of Schisler started a write-in campaign that successfully placed Schisler on the November ballot. In a surprising upset, he defeated incumbent Robert T. McLoskey in the predominantly Republican district which included Fulton, Henderson, Henry, Knox, Mercer, Rock Island and Warren counties in Western Illinois. Upon being sworn in, he was assigned to the House Science and Astronautics Committee. While in Congress, he was a supporter of President Johnson's agenda voting in favor of his Great Society legislation including the Voting Rights Act of 1965, the creation of Medicare and Medicaid, and the Higher Education Act of 1965. He was in favor of home-rule for Washington, D.C. and signed a discharge petition to get President Johnson’s preferred bill out of committee. He voted against B.F. Sisk’s compromise bill that provided home rule, but only with numerous delays and stipulations. He was a supporter of repealing the "right to work" provisions in Taft Hartley. In 1965, court order reapportionment of congressional districts moved Whiteside County into the 19th district bringing thousands of Republican voters into the already heavily Republican district. Shortly after, State Representative Tom Railsback of Moline announced his intention to stand against Schisler in the 1966 general election. Schisler was unable to overcome the partisan tilt of the new district and lost to Railsback in November. Schisler’s cause was further hurt by the widespread belief that the White House was apathetic to his reelection bid. After his loss, he was appointed as an assistant to Governor Otto Kerner Jr. leading the newly created Office of Intergovernmental Cooperation. The office was designed to coordinate state, federal and local programs and projects. He was also the staff liaison for the General Assembly’s Intergovernmental Cooperation Commission. When Kerner resigned, he continued this role under Samuel H. Shapiro.
After briefly mulling a rematch against Railsback, Schisler chose to run for one of the three spots in the Illinois House of Representative’s 46th district which included Fulton and Tazewell counties along with the southern portion of Peoria County, Illinois. He and incumbent George Saal ran as the Democratic candidates against Republican incumbents Wilbur H. Lauterbach and J. Norman Shade. Despite hopes that a joint Schisler-Saal slate would allow Democrats to take a majority of the 46th district’s seats, only Schisler was elected. He was appointed to the Education Committee and Higher Education Committee. The decennial reapportionment process in 1971 moved him to the 48th district. The 48th included Fulton County and portions of Peoria and Tazewell counties from the 46th district. However, it also added new territory in Adams, Brown, Cass, Mason and Schuyler counties. When the Democratic Party took a majority in the Illinois House of Representatives after the 1974 election, Schisler was appointed chair of the Agriculture Committee. He was also a member of the Illinois-Mississippi Canal and Sinnissippi Lake Commission, the Energy Resource and Recreation Council. Five months into the Iran–United States hostage crisis, Schisler sponsored a nonbinding resolution urging Illinois’ public and private universities not to re-enroll current or new Iranian students for the upcoming school year. Later that year, he voted against the ratification of the Equal Rights Amendment and accused pro-ERA advocates of attempting to bribe him prior to the ratification vote. He lost reelection in 1980, finishing fourth of four candidates for three seats in the 48th district.
