GPS2 (gene)
G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.Function
This gene encodes a protein involved in G protein-mitogen-activated protein kinase signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 function.Interactions
GPS2 has been shown to interact with:
