Warne was born in Westminster in 1825, sixth and youngest son of the twelve children of Edmund Warne, a builder, and wife Matilda. Educated privately in Soho, he joined, aged fourteen, his brother William Henry Warne, and his brother-in-law George Routledge, in the retail bookselling business which Routledge had founded in 1836 in Ryder's Court, Leicester Square. Routledge started a publishing business in 1843, and in 1851 Warne became a partner in the firm, which was then styled Routledge & Co.; the name was changed to Routledge, Warne & Routledge in 1858 on Routledge's son, Robert Warne Routledge, becoming a partner. From 1851 to 1865 Warne was largely identified with the success of the firm. In 1865, on the advice of the publisher George Smith, of Smith, Elder & Co., Warne began an independent publishing career; he was joined by Edward James Dodd, and by A. W. Duret, who left the firm of Dalziel Brothers to join him. An American branch was established in New York in 1881.
Chandos Classics, Nuttall's Dictionary
Warne effectively emulated Routledge's ambition to popularise well-regarded literature. In 1868 he inaugurated The Chandos Classics: there were 154 titles in the series, and five million copies were sold. The series included an edition of Shakespeare which sold 340,000 copies. Nuttall's Dictionary, which was originally published by Routledge, Warne & Routledge in 1863, was first issued by Warne in January 1867, when 668,000 copies were soon sold. In 1886 a revised edition appeared, which sold nearly one million copies by 1911.
Children's books
Warne was active in the publication of coloured picture books for children. He inaugurated a new era between 1870 and 1880 by his issue of the Aunt Louisa books, which were followed by new editions of Edward Lear's A Book of Nonsense, by the children's books of Randolph Caldecott, and later by the works of Kate Greenaway and Walter Crane. In the field of fiction Warne issued Benjamin Disraeli's novels before their transfer to Messrs. Longman in 1870, and published in London most of Frances Hodgson Burnett's novels, including Little Lord Fauntleroy.
Magazines
He also first introduced to the English reading public the three American magazines The Century Magazine, St. Nicholas Magazine, and Scribner's Monthly.
Later life
In 1895 Warne, with his partner Dodd, left the business, and he was succeeded by his three surviving sons, Harold Edmund, William Fruing and Norman. He died at his home, 8 Bedford Square, on 7 November 1901, and was buried at Highgate Cemetery. He married on 6 July 1852, Louisa Jane, daughter of William Fruing of Jersey: they had seven sons and three daughters. Three sons and two daughters survived him.