In 2007, Guevara participated in the protests to end of the RCTV concession. Guevara and other student leaders actively participated in the electoral campaign for the "NO" against the Constitutional Referendum. In those elections of December 2007, the opposition conquered its first electoral triump, and Guevara consolidated as political leader. In 2008, Freddy Guevara ran for Caracas Metropolitan Council at the regional elections of November of that year, winning and becoming the youngest Councilman. and highest voted in the history of Venezuuela, obtaining 81.14% of the votes. Freddy Guevara was announced, in June 2015, as a consensus candidate for the MUD by the Miranda State for the elections of the National Assembly, which were held on December 6, 2015, as provided by the National Electoral Council. On August 7, 2015, Guevara formalized his candidacy as a unity candidate for deputy for Circumscription 2 of the Miranda State. Subsequently, the MUD presented its campaign command for the parliamentary elections, which was named "Comando Venezuela Unida". Guevara was part of the executive team for the Command, along with Jesus Torrealba, Henry Ramos Allup, Julio Borges and Enrique Márquez, with the aim of leading the work of Venezuelan opposition candidates throughout the country, in conjunction with all members of the opposition coalition. Guevara was sworn in as deputy with the rest of the MUD majority caucus on January 5, 2016, the day on which the National Assembly was installed for the 2016-2021 legislature. On January 14, 2016, Guevara presented before the plenary of the National Assembly an agreement to exhort the Venezuelan State to comply with the decisions, resolutions, opinions and acts issued by international human rights organizations. The text, which was approved by a parliamentary majority, requests compliance with the opinions of international entities on human rights, in which judges, courts and other public bodies are encouraged to execute measures, opinions and acts issued by organizations such as the UN and the OAS. The measure benefits prisoners and political persecuted expressly mentioned in the document, including Miguel Henrique Otero, Leopoldo Lopez, Antonio Ledezma, Judge Maria Lourdes Afiuni, among others. When a Constituent Assembly was promoted with the support of Nicolás Maduro's government to draft a new constitution for Venezuela in May, 2017, Guevara and the Democratic Unity Roundtable boycotted the election claiming that the Constituent Assembly was "a trick to keep in power." Since the opposition did not participate in the election, the incumbent Great Patriotic Pole won almost all seats in the assembly by default. At the end of October, 2017, Freddy Guevara, declared that his political Popular Will will not participate in any elections called by Maduro's government "as a mechanism of denunciation against the dictatorship."
End of parliamentary immunity
On November 3, 2017, the Supreme Court disqualifies his parliamentary immunity after being accused of instigating violence during opposition protests. The Inter-American Commission on Human Rights expressed its concern over the suspension of Guevara's parliamentary immunity. On November 5, 2017, he fled to the official residence of the Chilean ambassador in Caracas. A statement issued by the Chilean Foreign Ministry notes that "The Government of Chile has granted the quality of guest of our Embassy." It added that “In the face of what he deemed immediate threats against his security and personal wellbeing, he has requested the protection of Chile.” From his refuge at the embassy Guevara stated: "Very soon we will see each other in the streets marching to Miraflores, not to overthrow Maduro, but to swear in a new President:"
