Born on Crete on 22 August 1511, Portus was orphaned early. He studied in his youth with Arsenius Apostolius. He went to study in Italy thanks to the generosity of a family friend. He studied for six years in Padova, and then went to Venice, where he was admitted to the city's Greek school, where he soon became the director. During the decade from 1526 to 1535, one should also note his important activity as a copyist of Greek manuscripts. However, he was an adherent of Reformed Christianity, and certain mocking remarks that he made about the customs of traditional Christian religion, such as fasting and veneration of images, caused him to leave Venice. In 1536, Portus obtained a Chair in Greek at Modena, although he was unwilling to sign the declaration of faith which was required of public officials. In 1542, he was hired by Renée of France, the Duchess of Ferrara, as tutor to her sons, and she also entrusted to him the secret correspondence that she was maintaining with John Calvin. He was admitted to the Accademia dei Filareti, founded in Ferrara in 1554, and spoke before the Duchess a speech in praise of the Greek language. After the death of the Duke of Ferrara, Ercole II d'Este, in 1559, the Duchess returned to France. In fear of the Inquisition because of his religious views, Portus left Ferrara with his family, and spent some time in the area of Friuli before settling in Geneva, becoming a citizen of Geneva in 1562. In the same year, he was appointed to the Chair of Greek at the University of Geneva, which he occupied until his death. One of his most important students was Isaac Casaubon, whom he recommended to succeed him. After the St. Bartholomew's Day massacre in 1572, he had a polemical correspondence with his former colleague Pierre Charpentier, which became the instrument of French governmental propaganda and justified the massacre through the existence of a pretended plot against the royal family. Portus died in Geneva on 5 June 1581.
1569: Oἱ ἐν ῥητορικῇ τέχνῃ κορυφαίοι, Aphthonius, Hermogenes et Dionysus Longinus praestantissimi artis rhetorices magistri, opera industriaque illustrati et expoliti, Genevae.
1573: Ad Petri Carpentarii Causidici virulentam epistolam, responsio Francisci Porti... pro causariorum quos vocat innocentia.
1574: Response de François Portus Candiot, aux lettres diffamatoires de Pierre Carpentier,... pour l'innocence des fidèles serviteurs de Dieu... massacrez le 24 jour d'aoust 1572, appellez factieux par ce plaidereau, traduite nouvellement de latin en françois.
1580: Homeri Ilias, postrema editio ... a innumeris in locis emendata, Genevae.
1583: Francisci Porti... Commentarii in Pindari Olympia, Pythia, Nemea, Isthmia, Genevae.
1584: Francisci Porti Cretensis in omnes Sophoclis tragoedias προλεγόμενα, ut vulgò vocantur. In quibus Ipsa Poêtæ vita, genùsque dicendi declaratur. De Tragœdia, eiusque origine, et de Tragœdiæ, atque Comœdiæ discrimine paucis agitur. Sophoclis, et Euripidis collatio brevis instituitur, et quibus in rebus vterque potissimùm excellat, apertè demonstratur. Singularum verò Tragœdiarum Argumenta cum artificio Rhetorico separatim exponuntur. His addita ΠΑΡΑΣΚΕΥΗ´ ad orationem Demosthenis περὶ παραπρεσβείας, cui accesserunt Sex Oratiunculæ Latinæ, quas idem F.P. olim in Illustriss. Ducis Ferrariensis Academia Mutinensi Linguæ Græcæ Professor habuit. Singulis Oratiunculis suum argumentum paucis est ascriptum, Morgiis.
1586: Francisci Porti... Commentarii in varia Xenophontis opuscula, Lausannae.
1590: Apollonii Alexandrini de syntaxi... libri IV.
1592: Lexicon graecolatinum R. CONSTANTINI. Secunda hac editio partim ipsius authoris partim ... auctum, Genevae.
1594: Thucydidis, Olori filii, de Bello Peloponnesiaco libri octo. Iidem latine, ex interpretatione Laurentii Vallae, ab Henrico Stephano nuper recognita, quam Aemilius Portus, Francisci Porti Cretensis f., paternos commentarios accurate sequutus, ab infinita ... errorum multitudine ... repurgavit ... in hac postrema editione, Francofurti.
1598: Aristotelis Artis rhetoricae, sive de arte dicendi, libri III, a M. Aemilio Porto... nova interpretatione illustrati; item Francisci Porti... in eosdem libros perpetui latini commentarii, Spirae.