Harper received an A.B. in 1914 and a Ph.D. in 1925 from Cornell University. He taught briefly at Swarthmore College, but beyond that he worked for museums, government agencies and research agencies. In 1914 Harper made his first trip to northern Canada on an expedition to Lake Athabasca working as a zoologist for the Geological Survey of Canada. Between 1917 and 1919 Harper served as a rodent control officer in France with the United States Army's 79th Division. He returned to Athabasca in 1920, Nueltin Lake in southern Keewatin in 1947 and the Ungava Peninsula in 1953, his last trip north. Harper published notable works on the caribou of Keewatin, the birds of the Ungava Peninsula, and the Montagnais of the Ungava.
Research
From 1917 through the 1950s Harper spent significant time researching the work of the early North American naturalists John Bartram and his son William Bartram. Harper traced the Bartrams' travels in the American South and helped revive both scientific and popular interest in the Bartrams' work, while keeping notebooks on his fieldworks as early as in 1912. Harper's research into the Bartrams was funded by grants from the John Bartram Association in Philadelphia, the American Philosophical Society, and the Guggenheim Foundation among others. Extensive publications on both of the Bartrams included annotated editions of John Bartram's "Diary of a Journey through the Carolinas, Georgia, and Florida 1765-1766"; William Bartram's "Report to Dr. John Fothergill 1773-1774" and an annotated The Travels of William Bartram: Naturalist’s Edition first published in Philadelphia in 1791. Harper published on the mammals and folklore of the Okefenokee Swamp, including recordings of the local music. He also published on the "extinct and vanishing" mammals of the old world. His papers are held in the Kenneth Spencer Research Library at the University of Kansas.
Publications
Harper authored about 135 publications including:
"The Vultur Sacra of William Bartram", written by William Bartram, edited by F. Harper. Swarthmore, Pa, 1936?,
"The Bartram trail through the southeastern states", Chicago, 1939.
"William Bartram's names of birds", Rochester:, 1942?
"John Bartram's Diary ; and William Bartram's Travels, edited by F. Harper, "Transactions of American Philosophy Society", n.s., 33, Philadelphia: APS, 1944.
"Diary of a Journey through the Carolinas, Georgia, and Florida, from July 1, 1765 to April 10, 1766" edited by F. Harper.
"Travels in Georgia and Florida, 1773-74. A Report to Dr. John Fothergill" edited by Francis Harper.
The Travels of William Bartram: Naturalist’s Edition, edited by Francis Harper, University of Georgia Press:,.