In medicine, a forme fruste is an atypical or attenuated manifestation of a disease or syndrome, with the implications of incompleteness, partial presence or aborted state. The context is usually one of a well defined clinical or pathological entity, which the case at hand almost — but not quite — fits. An opposite term in medicine, forme pleine — seldom used by English-speaking physicians — means the complete, or full-blown, form of a disease.
The Latin phrase frustra esse means "to be mistaken" or "to be confused". As a technical term in French, the cognatefruste has been used in two related ways. First, as an antiquarian’s term it refers to a coin, medal or ancient stone on which figures and characters can no longer be recognized due to wear. Secondly, it was employed in natural history to denote mollusk shells whose striations, grooves or tips were worn down. By extension, this sense could be applied to sculpture, pottery, or other objects of great antiquity. It was in this sense of "indistinctness due to wear or through long use" that the great French internistArmand Trousseau first employed the term in connection with an obscured form of Graves' disease, which he described as a "…maladie dite fruste par l’absence du goitre et de l’exophthalmie" The sense of the term in medicine has slightly evolved to mean a "not fully developed form of an illness", rather than simply an obscure form. Sigmund Freud often used the term forme fruste in connection with incomplete or obscured cases of neuroses and psychoses and thus the literature of psychoanalysis is replete with it.
"Forme fruste cleft lip", also known as microform. This is the stated cause of the scar on actor Joaquin Phoenix's upper lip
"'Formes fruste of Churg-Strauss syndrome" have also been described as eosinophilic vasculitis and/or eosinophilic granulomas in isolated organs without evidence of systemic disease
"'Formes fruste type of Calcaneonavicular Coalition", the mildest type of CN coalition prior to Fibrous, Cartilaginous, or osseous types.
"Forme fruste Choledochal Cyst", variant of Choledocal cyst described in children in which there is Anomalous Pancreatico Biliary Ductal Junction with minimal dilatation of Bile duct in children and associated biliary and/ or pancreatic symptoms. Treatment of choice is bile duct excision. Reason for surgery is significant risk of malignancy and symptomatic relief of symptoms.
"Forme fruste Rett Syndrome", variant of Rett Syndrome which has a later age of onset compared with the classical form, with regression occurring between 1 and 3 years of age; hand use is sometimes preserved with minimal stereotypic movements
unilateral papillary cystadenoma is supposed to be forme fruste of VHL disease
"'Forme fruste of an epileptiform discharge", an EEG abnormality which appears similar to an epileptiform discharge but with a poorly-defined or nonstereotypic morphology, or with a more limited or fragmented cephalic distribution. This abnormality may represent a discharge which is less well-formed due to treatment with medications, or may be seen as an age-limited epilepsy syndrome is remitting.
"'Forme fruste lupus", incipient, or hidden form, lupus. Seropositivity without clinical findings.
"Forme fruste tuberous sclerosis" a reduced phenotypic expression of tuberous sclerosis.
"Forme fruste Charcot-Marie-Tooth disease" manifests as pes cavus and absent ankle jerks only.
"Dissociative Identity Disorder, Forme Fruste" a patient will present with an internal mental milieu of strong mental "characters" but lacks the following dissociative traits: amnesiac periods and distress over the disorder.
Forme fruste bipolar disorder - a variant of bipolar disorder characterised by regularly alternating periods of both heightened and depressed mood, neither of which meet the full criteria for mania, hypomania or depression. Forme fruste schizophrenia forms - Cluster A personality disorders which represent an accentuated variant of the whole schizophrenic process or the paranoid subtype specifically. Schizoid personality disorder, the third Cluster A personality disorder, is often also considered a "schizophrenia spectrum disorder."
