SR 72 begins at an intersection with the southern terminus of SR 758 to the east of the Gulf of Mexico in Siesta Key, Sarasota County, heading northeast on Stickney Point Road, a four-lane divided highway. The road passes through commercial areas, crossing the Intracoastal Waterway on a drawbridge. The state road heads into Gulf Gate Estates, passing through residential areas before heading into a commercial area and crossing US 41/SR 45. Past this intersection, SR 72 passes more homes and businesses as a seven-lane road with a center left-turn lane, curving east onto Clark Road at the Swift Road intersection. The road continues through developed areas, crossing South Lockwood Ridge Road, CR 773, and Sawyer Road. The state road becomes a six-lane divided highway and intersects McIntosh Road as it crosses a Seminole Gulf Railway line. SR 72 passes more businesses and intersects Sawyer Loop Road, Honore Avenue, and Gantt Road before coming to an interchange with I-75/SR 93 near Bee Ridge. Past this interchange, the state road narrows to four lanes before becoming a two-lane undivided road as it heads through residential areas, passing to the north of Twin Lakes Park. The road turns to the southeast and heads into a mix of wooded neighborhoods and fields, becoming an unnamed road. SR 72 curves east again and runs through rural areas of woods and swamps. The road enters Myakka River State Park and turns southeast. The state road continues through wooded swamps within the state park, heading east again. SR 72 leaves Myakka River State Park and passes through areas of fields and trees. The road crosses into DeSoto County and continues through rural areas for several more miles, intersecting CR 769. SR 72 turns northeast and passes through farmland and trees with some homes, intersecting CR 661 before ending at an intersection with SR 70 to the west of Arcadia.
Future
Starting in the Summer of 2021 the interchange with I-75 will be upgraded to a diverging diamond interchange. The on and off ramps on I-75 will be reconstructed as well as a auxiliary lane. Also noise barrier wall, sidewalks and bike lanes will be added along SR 72. The project is expected to cost around 51 million dollars and will take about two years to complete.
Major intersections
County Road 72A
County Road 72A is a west-to-east suffixed alternate of SR 72. The road is named "Proctor Road," and much of it is four lanes wide. It begins as a four-lane undivided highway at US 41 and doesn't become a divided highway until it reaches the Sarasota County Technical Institute. At McIntosh Road it narrows to a two-lane undivided highway. At Honore Avenue it widens to a four-lane divided highway. After the intersection of Cattleman Road and Grove Point Boulevard the road narrows down to a two-lane undivided highway before crossing over I-75 with no access, then returns to ground level after a power sub-station on the northeast corner of the overpass. After the intersection of a one-lane dead end street named Falcon Place, it curves to the southeast where it will eventually meet up with its parent route at the intersection with Dove Avenue. A former right of way of the road can be seen on the northeast corner of the terminus.
