A Winger and attacking midfielder, Jozefzoon began his career with spells at CTO '70 and AFC. He joined the Ajax Youth Academy in 2006 and signed a three-year professional contract in June 2008. Jozefzoon won his maiden call into the first team squad for the opening match of the 2010–11 Eredivisie season versus FC Groningen and remained an unused substitute during the 2–2 draw. He made his senior debut six days later, replacing Urby Emanuelson at half time during a 4–2 win over SBV Vitesse. He scored his only goal for the club in a 5–0 KNVB Becker third round win over MVV Maastricht on 22 September 2010. After five appearances during the 2010–11 season, Jozefzoon signed a one-year contract extension in June 2011, but spent the 2011–12 season away on loan and was released at the end of the season.
On 25 May 2012, Jozefzoon joined Eredivisie club RKC Waalwijk on a free transfer, signing a two-year contract with an option for a third year. He made 36 appearances and scored seven goals during the 2012–13 season before departing the Mandemakers Stadion in June 2013.
PSV Eindhoven
In June 2013, Jozefzoon joined Eredivisie giants PSV Eindhoven for a €400,000 fee. Despite making 25 appearances and scoring four goals during his debut season, he failed to fully break into the first team at the Philips Stadion. Jozefzoon's 15 league appearances during the 2014–15 season were enough to win him an Eredivisie winners' medal, the first silverware of his career. After largely falling out of the first team picture through 2015 and 2016 due to an anterior cruciate ligament injury, however he won his second Eredivisie winners' medal during the 2015–16 Jozefzoon left the club in January 2017.
On 27 January 2017, Jozefzoon moved to England to join Championship club Brentford for an undisclosed fee on a deal until the end of the 2016–17 season, with an option to extend for a further year. He made his debut four days later, playing the first 71 minutes of a 3–0 win over Aston Villa at Griffin Park. With both lacking stamina after little football during the first half of the season, head coachDean Smith rotated Jozefzoon and Sergi Canós on the right wing through to the end of the season, often with one substituting the other. Jozefzoon scored his first Bees goal on his 16th appearance, with the equaliser in a 1–1 draw with Barnsley on 17 April. Jozefzoon finished the season with 19 appearances and the club extended his contract by two years. Despite Sergi Canós suffering an injury, the signing of Ollie Watkins and the form of Josh Clarke meant that Jozefzoon failed to make the right wing berth his own during the early months of the 2017–18 season. Injury to Rico Henryin September saw Josh Clarke move to left back as cover, which allowed Jozefzoon to establish himself as a first choice wide option. He ended the 2017–18 season with 43 appearances and seven goals.
Derby County
After a £1.5m bid from Derby County was rejected by Brentford on 4 July 2018, on 18 July, a follow-up bid of £2.75m was accepted from Derby for the player. On 19 July, Brentford also accepted a matching rival bid for the player from Leeds United. He signed for Derby on 20 July 2018. He made his debut on 11 August in a 1–4 loss against Leeds United.
Jozefzoon was born in Saint-Laurent-du-Maroni, French Guiana and moved with his Surinamese parents, six brothers and two sisters to the Netherlands at age two.
