Mkhize was born in 1932 in Umzumbe, NatalSouth Coast. She started aware about politic at age 16 while attending a Roman Catholic school on the South Coast. Mkhize began fighting apartheid and took part in the Defiance Campaign in 1952. A photo of her burning her pass book was taken by Ranjith Kally and is now exhibited as both art and a record of that struggle. She was subsequently banned. Despite the ban on her political activity, she used her place of work, a sewing factory which placed on Lakhani Chamber, Durban to communicate and organise. During formulation of Freedom Charter, her bus which on the way to Kliptown for Congress of People was turned back by the police and go back to Natal. In 1954, Mkhize with Lilian Ngoyi, Helen Joseph, Fatima Meer and other women became the founding members of the Federation of South African Women. Mkhize organized women to participate in the Women's March in 1956, but was not able to go herself when the bus she was traveling on to reach Pretoria was turned back by police. She was one of thel leader from the Potato and Tobacco boycotts against industries which was colluding with apartheid in 1959.After African National Congress was banned in 1960, as a member of South African Communist Party, she continue the struggle by joining South African Congress of Trade Unions until the organization supressed by the government. In June 1968, she was banned again for five years under the Suppression of Communism Act. In the 1970s, Mkhize was involved with the Release Mandela Campaign and used her home to hide others from security forces. During 1980s, she has been pursuing to solve education and housing crisis in Lamontville. Mkhize helped raise money to helped educate students who were refused education in public school because of their parents' political involvement by going to Amsterdam. Phambili High School was founded after this trip. She was also one of the founding member of United Democratic Front in 1983 and in the same year, she was mobilizing women from other racial group with Natal Organization of Women. In the 1994 elections, she became a councillor for ward 75 which she held until 7 July 1999. She founded Zikhulise Cleaning, Maintenance and Transport company when she was a councillor in eThekwini on 1997.
Personal Life
She married his husband, Amos Mswane in the 1950s and lived in Durban. They had four children. Her boys named Mandla and Thulani. Khosi and Shawn Mkhize were her daughter.