Dr. Denton has published reports, books, and peer-reviewed articles that advocate for a multi-dimensional view of development that renders it more sustainable. Fatima Denton worked as a policy analyst and project coordinator with the energy program of Enda Tiers Monde in Senegal. Her work addressed issues including sustainable development, climate and gender, climate change vulnerability and adaptation, food security, local governance, water, and energy poverty in the Sahel. Her expertise in Benin has contributed to establishing a framework that evaluates adaptive interventions across Africa. "Transformational change" demands local ownership of widespread initiatives that are supported by the higher-level stakeholders. She advocates for a new narrative on climate change in Africa by viewing it as an opportunity. Instead of “standing knee-deep in the river and dying of thirst,” she argues that climate change strategies and agricultural development can be united, or similarly, increased public engagement can elicit technological innovation. She specifically argues that the strategic use of African resources has the capacity to decrease African nations’ dependency on the international community for sustainable growth. Fatima Denton worked as a senior energy planner with the United Nations Environment Programme at Risø Centre in Denmark. She was a member of UNEP's Scientific and Technical Advisory Panel. She has paid particular attention to the role of women, pointing out their absence from planning and development processes, the unequal impact of disasters and climate change given gendered labour roles and social status, and the need to include women in developing effective energy policies. Solutions cannot solely focus on technology and infrastructure; they must also consider community-focused research and analysis of multiple socio-economic and political-institutional factors leading to vulnerability. For example, she contributed to research that suggests the adoption of new agricultural strategies, are positively correlated with young workers, and in female-headed households. Fatima Denton joined the International Development Research Centre in 2006, where she has been a leader in strategies for climate change adaptation. As Programme Leader at the IDCR, Denton was involved in the management of numerous high profile research initiatives and projects that promoted environmental sustainability across African countries. As coordinator of the , Denton played a key role advocating for the impactful and decisive goals that African nations should strive for going into the COP 21 meetings for the development of the UN Paris Agreement. In the interest of Africa’s particular vulnerability to the effects of global warming, she outlined that an assertive and responsible approach should be adopted by all countries, regardless of the varying contribution to climate change. In 2017, Denton stated her advocacy for Climate Information Services and its more enthusiastic implementation into the policies of African countries in an effort to counteract poverty and the negative effects of climate. On September 10th 2018, Dr. Denton was appointed as Director at the Ghanaian branch of the United Nations University. Specifically, at the . She also contributed to the as a trustee and as a member in the international research program Future Earth advisory board.