FOLFOXIRI

• FOL – folinic acid, a vitamin B derivative that modulates/potentiates/reduces the side effects of fluorouracil;
• F – fluorouracil, a pyrimidine analog and antimetabolite which incorporates into the DNA molecule and stops DNA synthesis;
• OX – oxaliplatin, a platinum-based antineoplastic agent, which inhibits DNA repair and/or DNA synthesis;
• IRI – irinotecan, a topoisomerase inhibitor, which prevents DNA from uncoiling and duplicating.