FKBP7
FK506 binding protein 7 is a protein that in humans is encoded by the FKBP7 gene. The gene is also known as FKBP23 and PPIase. FKBP7 belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. Members of this family exhibit PPIase activity and function as molecular chaperones. The orthologous protein in mouse is located in the endoplasmic reticulum and binds calcium.Model organisms
s have been used in the study of FKBP7 function. A conditional knockout mouse line, called Fkbp7tm2aWtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.
Twenty three tests were carried out on mutant mice, but no significant abnormalities were observed.
