Throughout history, prisoners have been frequent participants in scientific, medical and social human subject research. Some of the research involving prisoners has been exploitative and cruel. Many of the modern protections for human subjects evolved in response to the abuses in prisoner research. Research involving prisoners is still conducted today, but prisoners are now one of the most highly protected groups of human subjects
Requirements of research involving prisoners
According to the Common Rule, prisoners may only be included in human subjects research when the research involves no more than a minimal risk of harm.
Prisoners can consent, although their consent cannot be said to be completely voluntary due to their compromised and dependent status. Their status as imprisoned human subjects becomes even more ethically problematic when investigators offer incentives such as parole, phone calls, or objects that are normally unavailable to prisoners.
was a CIA-run human experiment program from 1953-1973 where volunteers, prisoners and unwitting subjects were administered hallucinogenic drugs in attempt to develop incapacitating substances and chemical mind control agents, in an operation run by Sidney Gottlieb. Numerous experiments were done on prisoners throughout the US. Many prisoners eventually filed lawsuits and these actions brought about many more investigations and suits against doctors, hospitals and pharmaceutical companies. Experiments included high-risk cancer treatments, the application of strong skin creams, new cosmetics, dioxin and high doses of LSD. Many incidents were documented in government reports, ACLU findings and various books including Acres of Skin by Allen Hornblum. The Stateville Penitentiary Malaria Study is one of many examples. The Plutonium Files, for which Eileen Welsome won a Pulitzer Prize, documents the early human tests of the toxicity of plutonium and uranium on people. American oncologist Chester M. Southam injected HeLa cells into Ohio State Penitentiary inmates without informed consent in order to see if people could become immune to cancer.
The Herero and Namaqua Genocide in present-day Namibia, in Southern Africa, resulted in a large number of prisoners in concentration camps. These prisoners were used as medical test subjects by German agents. During the second World War, Nazi human experimentation occurred in Germany with particular bias towards euthanasia. At the war's conclusion, 23 Nazi doctors and scientists were tried for the murder of concentration camp inmates who were used as research subjects. Of the 23 professionals tried at Nuremberg, 15 were convicted. Seven of them were condemned to death by hanging and eight received prison sentences from 10 years to life. Eight professionals were acquitted. The result of these proceedings was the Nuremberg Code. It includes the following guidelines, among others, for researchers:
