Examples of in vitro transdifferentiation by lineage-instructive approach

• Mouse fibroblasts, chondroblasts, and pigmented retinal epithelial cells → myoblasts
• Fibroblasts → melanocytes
• Glial cells → neurons
• Erythorid-megakaryocytic cells → monocytic cells
• B-cell progenitors → functional macrophages
• Rat hepatic cell line → insulin-producing cells
• Fibroblasts → macrophage-like cells
• Postnatal cardiac and dermal fibroblasts → cardiomyocytes
• Fibroblasts → heptaocyte-like cells or
• Fibroblasts → neurons
• Human fibroblasts → neurons or
• Human fibroblasts → functional neurons
• Fibroblasts → dopaminergic neurons or
• Astrocytes → dopaminergic neurons