Eulalia Pérez was born in Loreto, the capital on the Baja California Peninsula of the Las Californias Province in the Viceroyalty of New Spain, to Diego Pérez of Salamanca, Spain and Antonia Rosalia Cotes. Macedonio Gonzalez, one of Eulalia's nephews, knew Antonia Cota as Lucia Valenzuela according to Eulalia's English born son-in-law and author Michael C. White, aka: Miguel Blanco. Diego Pérez was a ship captain, thought to come from Salamanca—family members have been unable to trace records of his commission through the Archivo General de Indias or in Loreto, which has been ravaged by hurricanes over the centuries. Her siblings were Teresa, Petra, Juana, Josefa, Bernardo, and León. According to family lore, Capitan Pérez taught his daughter how to read and write, a fact later important to her survival and eventual prominence. She married Spanish army Sergeant Miguel Antonio Guillén at age fifteen. He was in the company at the Presidio of San Diego. They moved from Baja about 1800—on foot in those days—to the garrison at the new Mission San Gabriel, with their children Petra, Rosaria, and Isidoro. Miguel died while later serving at the garrison at San Diego, leaving Pérez with several children.
Misión San Gabriel
Pérez managed to obtain employment at Misión San Gabriel, initially as cook and midwife for those such as Governor Pío Pico. She was eventually made "keeper of the keys" of the mission itself.
Rancho del Rincon del San Pascual
When she retired, Mexican Governor José Figueroa rewarded Pérez as the grantee of Rancho del Rincón de San Pascual with her husband Juan Mariné. Rancho San Pascual encompasses the present day cities of Pasadena, South Pasadena, and San Marino. This had been part of the homeland of the Tongva-GabrieleñoNative Americans for thousands of years. Within the independent Mexican territory of Alta California, as a woman Pérez was unable to have ownership of property in her own name, so she married retired Mexican artillery lieutenant Juan Mariné. According to some descendants, Mariné and his sons lost all the land in a short time by gambling. In another narrative, one of Marine's sons, Fruto, was an active soldier and could not take charge of the Rancho. He sold it to José Pérez and Enrique Sepúlveda in 1839. Perez and Sepúlveda submitted a new land claim and in 1839 were re-granted their own title to Rancho San Pascual by Mexican Governor Juan Bautista Alvarado. Both built small adobe houses near the Arroyo Seco. Jose Perez died in 1841 and Enrique Sepulveda died in 1843, which left Rancho San Pascual abandoned until a new grantee later that year.
Pérez died in the Los Angeles area on June 11, 1878. Her death certificate, located in the Santa Ana courthouse records that she lived to be 140, but descendants for the most part agree on more conservative figures like 110 or 112 years old, making her a famous centenarian of early California and of U.S. history. Eulalia Pérez de Guillén Mariné is one of only two non-clergy buried with the priests in the San Gabriel Mission courtyard cemetery. Although there are an unknown number of Native Americans from the Kizh tribe or Gabrielino in the courtyard cemetery, the priests were buried in a designated section immediately adjacent to the wall of the Mission in a place of honor. In Catholic tradition, burials closest to the most sacred areas of the church are reserved for individuals of stature, usually clergy. Eulalia being honored in this way, was a highly unusual honor at that time for a woman: a marble bench inscribed with her name marks the spot. Her numerous descendants married other Californios from other founding Spanish and Mexican families of pre-statehood California. Some of Eulalia Perez de Guillen Marine's descendants include:
Maria Rita de Guillen de la Ossa, wife of Don Jose Vicente de la Ossa, owners of Rancho de los Encinos in Encino, Los Angeles
Katherine Kevane Murray, champion of English for Spanish-speaking children in California public schools
Alexander Howison Murray Jr., twice mayor of Placerville
Patricia Murray Chambers
Victoria Duarte Cordova, California genealogist and historian,