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Etazolate
Etazolate
is an
anxiolytic
drug
which is a
pyrazolopyridine
derivative
and has
unique
pharmacological
properties
. It
acts
as a
positive allosteric modulator
of the
GABA
A
receptor
at the
barbiturate
binding site
, as an
adenosine
antagonist
of the A
1
and A
2
subtypes
, and as a
phosphodiesterase inhibitor
selective
for the
PDE4
isoform
. It is
currently
in
clinical trials
for the
treatment
of
Alzheimer's disease
.
Synthesis
