Pilkington was a friend of Horace Plunkett and George Russell. It was a speech by Russell at an annual general meeting of the Irish Agricultural Organization Society that inspired the foundation of the Society of the United Irishwomen by Anita Lett in 1910. Pilkington was the first volunteer organiser of the UI, and was a leading figure during its early years. She toured extensively in 1910, founding and organising new branches in the south and west of Ireland. County Wexford was deemed the most successful during this time. Pilkington arrived in County Donegal in December 1910, armed with a map and a thermos flask, whilst there she described emigration as a blight on rural Ireland. From this point on, female emigration became one of the major concerns of the UI. The 1911 pamphlet, The United Irishwomen: their work, place and ideals, was composed of three essays by Plunkett, Pilkington, and Russell, and a preface by Fr Thomas Finlay. Pilkington focused on the role of the UI in teaching and promoting rural housewives to establish home industries, maintain a cleanly home, to provide a healthy dietfor the family, and to take an active role in public and intellectual life. The pamphlet could have been a response to criticism, in particular as many objected to women's involvement in public affairs. Pilkington strongly believed in the need for women to work for the betterment of Ireland through their place in the home.
Artistic work
Pilkington was actively interested in the arts in Ireland. In 1910, she wrote an article in the New Ireland Review, expressing regret that Irish artists and critics didn't find their own Irish expression through an Irish school, rather than imitating European schools. She held up George Russell as an example of an individual artist who also invoked an Irish national narrative. Pilkington did not articulate clearly her own vision of Irish national identity, but believed it to be an important issue. As an artist, she painted scenes of Ireland and was exhibited by the Dublin Sketching Club in 1914 and 1915. She was shown regularly by the Water Colour Society of Ireland between 1921 and 1936, serving as the group's secretary for a time.
Later life
Pilkington was widowed in 1914. Later in life, she was an active member of the Central Catholic Library Association, acting as its president of the ladies' committee for a number of years. She died at 38 Wellington Road, Ballsbridge, Dublin, on 24 August 1936. She is interred in the Pilkington family vault, Tyrrellspass, County Westmeath.