Eccrine glands are the major sweat glands of the human body, found in virtually all skin, with the highest density in palm and soles, then on the head, but much less on the trunk and the extremities. In other mammals, they are relatively sparse, being found mainly on hairless areas such as foot pads. They reach their peak of development in humans, where they may number 200–400/cm² of skin surface. They produce a clear, odorless substance, sweat, consisting primarily of water. Eccrine glands are composed of an intraepidermal spiral duct, the "acrosyringium"; a dermal duct, consisting of a straight and coiled portion; and a secretory tubule, coiled deep in the dermis or hypodermis. The eccrine gland opens out through the sweat pore. The coiled portion is formed by two concentric layer of columnar or cuboidal epithelial cells. The epithelial cells are interposed by the myoepithelial cells. Myoepithelial cells support the secretory epithelial cells. The duct of eccrine gland is formed by two layers of cuboidal epithelial cells. Eccrine glands are active in thermoregulation by providing cooling from water evaporation of sweat secreted by the glands on the body surface and emotional induced sweating. The white sediment in otherwise colorless eccrine secretions is caused by evaporation that increases the concentration of salts. The odour from sweat is due to bacterial activity on the secretions of the apocrine sweat glands, a distinctly different type of sweat gland found in human skin. Eccrine glands are innervated by the sympathetic nervous system, primarily by cholinergic fibers whose discharge is altered primarily by changes in deepbody temperature, but by adrenergic fibers as well. The glands on palms and soles do not respond to temperature but secrete at times of emotional stress.
Secretion
The secretion of eccrine glands is a sterile, dilute electrolyte solution with primary components of bicarbonate, potassium, and sodium chloride, and other minor components such as glucose, pyruvate, lactate, cytokines, immunoglobulins, antimicrobial peptides, and many others. Relative to the plasma and extracellular fluid, the concentration of Na+ ions is much lower in sweat. Initially, within the eccrine glands, sweat has a high concentration of Na+ ions. The Na+ ions are re-absorbed into the tissue via the epithelial sodium channels that are located on the apical membrane of the cells that form the eccrine gland ducts. This re-uptake of Na+ ions reduces the loss of Na+ during the process of perspiration. Patients with the systemic pseudohypoaldosteronism syndrome who carry mutations in the ENaC subunit genes have salty sweat as they cannot reabsorb the salt in sweat. In these patients, Na+ ion concentrations can greatly increase. In people who have hyperhidrosis, the sweat glands overreact to stimuli and are just generally overactive, producing more sweat than normal. Similarly, cystic fibrosis patients also produce salty sweat. But in these cases, the problem is in the CFTR chloride transporter that is also located on the apical membrane of eccrine gland ducts. Dermicidin is a newly isolated antimicrobial peptide produced by the eccrine sweat glands.
