Asgharzadeh was a 24-year-old Industrial engineering student at a Sharif University of Technology in Tehran at the time of the Islamic revolution. He was the leader of the newly formed Office for Strengthening Unity, a group founded by Ayatollah Mohammad Beheshti to counter the influence among university students of the anti-theocratic Mojahedin-e Khalq. Asgharzadeh became well known as a leader of the embassy takeover. From 1982 to 1988, Asgharzadeh worked closely with future president Muhammad Khatami, who was then head of the official Kayhan newspaper and later became the minister of culture and Islamic guidance. Asgharzadeh also served as a military commander in the war with Iraq for six months. After 1988 Asgharzadeh began calling for more openness and "voicing his opposition to the clerics' policies." In 1988 Asgharzadeh was elected to Parliament representing a district in Tehran. By 1992 his "outspokenness" provoked the conservative Guardian Council into disqualifying him for running for most elected posts and sentencing him to a month in solitary confinement. After being released from prison he abandoned his career as an engineer and returned to school, studying political science at Tehran University, where, as of 2002, he was working on a doctorate. In 1996 he helped set up the Iranian reform movement that led to the election of Khatami a year later, and ran for municipal council. In 1998 Asgharzadeh was preaching the importance of city and village council elections that would build democracy in Iranfrom the ground up. He was beaten up in the city of Hamadan by men with iron bars, his glasses broken and suit torn, when he tried to give a lecture there. In early 2001 he was a city council member in Tehran, speaking out against the news blackout of his candidacy imposed by reformist papers, and the polarization of presidential elections. He attempted to run as a reformist presidential candidate in the 2001 election against then-incumbent President Mohammad Khatami, though aware of the "high possibility" he would be disqualified by the electoral supervisory body of the Guardian Council. He was later arrested for publishing the reformist Salam newspaper which was critical of the government. In his politics and journalism Asgharzadeh has strongly urged the Supreme Leader and other powerful clerics to adopt democratic reforms, such as freedom of the press and the elimination of veto powers they wield over political candidates and legislation. He is said to represent an Islamist faction "more rooted in the left-wing and egalitarian ethos of the revolution" than theocracy. In foreign policy, Asgharzadeh has been described as an advocate of "improved relations with the United States", who questioned President Khatami's handling of "an opportunity to mend relations with the United States" when he failed to follow up on a March 2000 acknowledgement by American Secretary of State Madeleine K. Albright of "American errors in its dealings with Iran, including Washington's support for a coup in 1953." On the other hand, according to Mahan Abedin, he is "probably the most determined and effective anti-American ideologue in the contemporary world", and an even "more determined opponent of American hegemony" than he was as a hostage-taker of Americans in 1979. In 2019, Asgharzadeh was interviewed by the Associated Press. He said that he regretted the embassy takeover and that Iranian student leaders bore sole responsibility: "Like Jesus Christ, I bear all the sins on my shoulders".
