East Main Street Historic District
- Batesville East Main Historic District
- East Main Street Commercial Historic District (Palmyra, New York)
- East Main Street Commercial Historic District (Statesboro, Georgia)
- East Main Street Historic District (Brevard, North Carolina)
- East Main Street Historic District (Bridgeport, Connecticut)
- East Main Street Historic District (Chesterfield, South Carolina)
- East Main Street Historic District (Christiansburg, Virginia)
- East Main Street Historic District (Danville, Kentucky)
- East Main Street Historic District (Forest City, North Carolina)
- East Main Street Historic District (Hillsboro, Ohio)
- East Main Street Historic District (Jackson, Tennessee)
- East Main Street Historic District (Murfreesboro, Tennessee)
- East Main Street Historic District (New Iberia, Louisiana)
- East Main Street Historic District (Pflugerville, Texas)
- East Main Street Historic District (Ravenna, Ohio)
- East Main Street Historic District (Richfield Springs, New York)
- East Main Street Historic District (Searsport, Maine)
- East Main Street Historic District (Waltham, Massachusetts)
- East Main Street Historic District (West Point, Mississippi)
- East Main Street Historic District (Westfield, New York)
- East Main Street Historic District (Wilmore, Kentucky)
- East Main Street Residential District (Marshallville, Georgia)
- East Main Street Residential Historic District (Cuero, Texas)
- East Main Street Residential Historic District (Lumpkin, Georgia)
- East Main Street Residential Historic District (Miles City, Montana)
- East Main Street and Exchange Street Historic District
- East Main Street-Cherry Street Historic District
- East Main Street-Douglass Heights Historic District
- East Main Street-Glen Miller Park Historic District
- East Main Street-Johnson Street Historic District
- East Main-Cherry Street Historic District
- East Main-High Street Historic District
- East Main-Mechanic Streets Historic District
- Georgetown East Main Street Residential District
- List of RHPs in CT
- List of RHPs in KY
- List of RHPs in MA
- List of RHPs in MS
- List of RHPs in MT
- List of RHPs in NC
- List of RHPs in OH
- List of RHPs in SC
- List of RHPs in TN
- List of RHPs in TX
- List of RHPs in VA
- Main Street Historic District (disambiguation)
- National Register of Historic Places listings in Bulloch County, Georgia
- National Register of Historic Places listings in Iberia Parish, Louisiana
- National Register of Historic Places listings in Independence County, Arkansas
- National Register of Historic Places listings in Jessamine County, Kentucky
- National Register of Historic Places listings in Macon County, Georgia
- National Register of Historic Places listings in Stewart County, Georgia
- National Register of Historic Places listings in Travis County, Texas
- National Register of Historic Places listings in Troup County, Georgia
- National Register of Historic Places listings in Waldo County, Maine
- National Register of Historic Places listings in Warren County, Kentucky
- North Main Street Historic District (disambiguation)
- South Main Street Historic District (disambiguation)
- Upper East Main Street District
- West Main Street Historic District (disambiguation)