Dupree had its start in 1910 by the building of the Milwaukee Railroad through that territory. The city derives its name from Fred Dupris, a pioneer settler.
As of the census of 2010, there were 525 people, 176 households, and 116 families residing in the city. The population density was. There were 203 housing units at an average density of. The racial makeup of the city was 29.3% White, 66.9% Native American, 0.4% from other races, and 3.4% from two or more races. Hispanic or Latino of any race were 4.2% of the population. There were 176 households, of which 44.9% had children under the age of 18 living with them, 38.1% were married couplesliving together, 21.6% had a female householder with no husband present, 6.3% had a male householder with no wife present, and 34.1% were non-families. 31.8% of all households were made up of individuals, and 10.8% had someone living alone who was 65 years of age or older. The average household size was 2.98 and the average family size was 3.83. The median age in the city was 27.6 years. 37.3% of residents were under the age of 18; 9% were between the ages of 18 and 24; 22% were from 25 to 44; 23.8% were from 45 to 64; and 7.8% were 65 years of age or older. The gender makeup of the city was 46.5% male and 53.5% female.
2000 census
As of the census of 2000, there were 434 people, 146 households, and 108 families residing in the city. The population density was 1,089.8 people per square mile. There were 171 housing units at an average density of 429.4 per square mile. The racial makeup of the city was 28.11% White, 70.74% Native American, and 1.15% from two or more races. Hispanic or Latino of any race were 0.92% of the population. There were 146 households, out of which 39.0% had children under the age of 18 living with them, 39.7% were married couples living together, 26.0% had a female householder with no husband present, and 26.0% were non-families. 24.0% of all households were made up of individuals, and 6.2% had someone living alone who was 65 years of age or older. The average household size was 2.97 and the average family size was 3.48. In the city, the population was spread out, with 37.1% under the age of 18, 9.4% from 18 to 24, 24.7% from 25 to 44, 20.0% from 45 to 64, and 8.8% who were 65 years of age or older. The median age was 28 years. For every 100 females, there were 80.8 males. For every 100 females age 18 and over, there were 79.6 males. The median income for a household in the city was $22,250, and the median income for a family was $20,781. Males had a median income of $21,667 versus $14,875 for females. The per capita income for the city was $8,206. About 41.9% of families and 52.1% of the population were below the poverty line, including 77.4% of those under age 18 and 17.0% of those age 65 or over.
