The Art Center traces its roots to 1916, when the Des Moines Association of Fine Arts established gallery space at the Public Library of Des Moines on the banks of the Des Moines River downtown. Several exhibitions were shown each year, and works of art were periodically purchased for the association's permanent collection. In 1938, the DMAF moved their collection to a building on Walnut Street. Planning for a permanent building began in 1943 after a sizeable donation from the trust of James D. Edmundson. In 1945, DMAF evolved into the Des Moines Art Center. A site along Grand Avenue in the city's Greenwood Park was designated as the preferred location. Construction began in 1945; the museum itself opened in 1948, with additional wings constructed in 1968 and 1985. In 2009, the Art Center expanded its mission to operate the Pappajohn Sculpture Park, located in Western Gateway Park downtown.
A large main gallery rotates through several exhibitions throughout the year, most of which are featured from one to three months at a time. These shows include solo shows by internationally recognized artists, travelling shows from other institutions, and group shows organized around a theme. The rest of the museum space highlights the permanent collections in various ways, including small spaces for short-term print and photography shows, a video gallery, and long-term installations organized both chronologically and thematically. Included on the grounds are outdoor sculptures and a rose garden. An external reflecting pool is surrounded on all sides by the museum. The architecture of the original museum wing was designed in a combination of Art Nouveau and Art Deco styles by Eliel Saarinen in 1945 and completed in 1948. The second addition, originally intended for large-scale sculpture, was designed in a Modernist style by I.M. Pei in 1966 and completed in 1968. Legend says that Pei designed the south windows, which look out onto the rose garden, to resemble "PEI", but he has denied this. The third wing was designed by Richard Meier and completed in 1985. This wing was designed to allow as much natural ambient light in as possible. The Art Center also includes a restaurant and a gift shop. Workshops, film festivals and lectures are conducted on a regular basis through the museums large studio program, with classes available for students of all ages. Museum hours are Tuesday, Wednesday, and Friday from 11am to 4pm, Thursday from 11am to 9pm, Saturday from 10am to 4pm, and Sunday from noon to 4pm. Admission is free.