De la Serna
de la Serna is a surname. Notable people with the name include:
- Jacobo de la Serna, American ceramic artist, Spanish Colonial scholar, and painter
- Jorge Juan Crespo de la Serna, Mexican artist, art critic and art historian
- José de la Serna e Hinojosa, Spanish general and Viceroy of Peru
- Juan Pérez de la Serna, seventh Archbishop of Mexico
- Pedro Gómez de la Serna, Spanish jurist and politician
- Ramón Gómez de la Serna, Spanish writer
- Rodrigo de la Serna, Argentine actor
