DeMayo reaction
The DeMayo reaction is a photochemical reaction in which the enol of a 1,3-diketone reacts with an alkene and the resulting cyclobutane ring undergoes a retro-aldol reaction to yield a 1,5-diketone:
The net effect is to add the two carbon atoms in the C=C double bond between the two carbonyl groups of the diketone. It is thus useful in syntheses both as a relatively selective way to join two parts of a molecule and as a way to apply the more developed chemistry of 1,3-diketone synthesis to 1,5-diketones. The first part is a cycloaddition. The ensuing retro-aldol cleavage is favored by the relative instability of the cyclobutane ring.
| An animation of the reaction mechanism |