Schlereth attended UNLV for one season as a member of the baseball team, but did not appear in any games. He then transferred to the University of Arizona, where he pitched for three seasons. During his time at Arizona, he pitched alongside former Detroit Tigers teammate Ryan Perry.
On December 9, 2009 Schlereth and Max Scherzer were traded to the Detroit Tigers as part of a three-team trade that brought Ian Kennedy and Edwin Jackson to the Diamondbacks. Schlereth spent the first half of the 2010 season with the Toledo Mud Hens, posting a 2.83 ERA and 45 strikeouts. He was called up by the Tigers on July 2, 2010 to replace Fu-Te Ni on the roster, who was sent down two days earlier. On August 15, 2011, Schlereth gave up Jim Thome's 600th home run against the Twins at Comerica Park. On November 30, 2012, the Tigers non-tendered Schlereth's contract, making him a free agent. He was then traded back to the Detroit Tigers from the Pittsburgh Pirates for cash, on June 24, 2014 and was assigned to the Detroit Tigers Triple a team, The Toledo Mud Hens.
On December 19, 2012, Schlereth was signed to minor league deal with the Baltimore Orioles with an invitation to spring training.
Pittsburgh Pirates
Schlereth signed a minor league deal with the Pittsburgh Pirates on December 18, 2013.
Return to Detroit
On June 24, 2014, the Tigers reacquired Schlereth from Pittsburgh in exchange for cash considerations, and was assigned to the Detroit Tigers' Triple-A affiliate, the Toledo Mud Hens. He posted a 4.50 ERA in 17 games with the Mud Hens. On January 14, 2015, the Tigers signed Schlereth to a minor league contract.
On January 18, 2016, Schlereth signed a minor league contract with the Toronto Blue Jays. He was released on June 30.
St. Louis Cardinals
On December 12, 2016, Schlereth signed a minor league contract with the St. Louis Cardinals that included an invitation to spring training. He was released on March 27, 2017.
On May 31, 2019, Schlereth signed with the Sugar Land Skeeters of the Atlantic League of Professional Baseball. He became a free agent following the season.
Personal life
Schlereth's father, Mark, was a professional football player who spent twelve seasons in the NFL with the Washington Redskins and Denver Broncos, and was a starting guard on three Super Bowl championship teams. The elder Schlereth was born and raised in Anchorage and played college football at Idaho; he is currently an NFL analyst on ESPN, and co-host of the morning edition of Denver's sports radio show, 104.3 The Fan. Schlereth was married on November 14, 2010, to his longtime girlfriend, Breanne Workman, a collegiate gymnast at Arizona. They have two daughters, Quinn Brielle Schlereth and Drew Sera Schlereth.
Repertoire
Schlereth predominantly is a two-pitch pitcher. He features a curveball in the high 70s and a fastball in the low 90s.