Daniel Carleton Gajdusek


Daniel Carleton Gajdusek was an American physician and medical researcher who was the co-recipient of the Nobel Prize in Physiology or Medicine in 1976 for work on an infectious agent which would later be identified as kuru, the first known human prion disease.
In 1996, Gajdusek was charged with child molestation and, after being convicted, spent 12 months in prison before entering a self-imposed exile in Europe, where he died a decade later. His papers are held at the National Library of Medicine in Bethesda, Maryland. and at the American Philosophical Society in Philadelphia, Pennsylvania.

Early life and education

Gajdusek's father, Karol Gajdusek, was a butcher, an ethnic Slovak from Büdöskő, Kingdom of Hungary. His maternal grandparents, ethnic Hungarians of the Calvinist faith, emigrated from Debrecen, Hungary. Gajdusek was born in Yonkers, New York, and graduated in 1943 from the University of Rochester, where he studied physics, biology, chemistry and mathematics. He obtained an M.D. from Harvard University in 1946 and performed postdoctoral research at Columbia University, the California Institute of Technology, and Harvard. In 1951, Gajdusek was drafted into the U.S. Army and assigned as a research virologist at the Walter Reed Army Medical Service Graduate School. In 1954, after his military discharge, he went to work as a visiting investigator at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia. There, he began the work that culminated in the Nobel prize.

Kuru research

Gajdusek's best-known work focused on kuru. This disease was rampant among the South Fore people of New Guinea in the 1950s and 1960s. Gajdusek connected the spread of the disease to the practice of funerary cannibalism by the South Fore. With elimination of cannibalism, kuru disappeared among the South Fore within a generation.
Gajdusek was introduced to the problem of kuru by Vincent Zigas, a district medical officer in the Fore Tribe region of New Guinea. Gajdusek provided the first medical description of this unique neurological disorder, which was miscast in the popular press as the "laughing sickness" because some patients displayed risus sardonicus as a symptom. He lived among the Fore, studied their language and culture, and performed autopsies on kuru victims.
Gajdusek concluded that kuru was transmitted by the ritualistic consumption of the brains of deceased relatives, which was practiced by the Fore. He then proved this hypothesis by successfully transmitting the disease to primates and demonstrating that it had an unusually long incubation period of several years. He did this by drilling holes into chimps' heads and placing pureed brain matter into the cerebellum. These animals then developed symptoms of kuru. This was the first demonstration of the infectious spread of a noninflammatory degenerative disease in humans.
Kuru was shown to have remarkable similarity to scrapie, a disease of sheep and goats caused by an unconventional infectious agent. Subsequently, additional human agents belonging to the same group were discovered. They include sporadic, familial, and variant Creutzfeldt–Jakob disease. Gajdusek recognized that diseases like Kuru and Creutzfeldt–Jakob disease were caused by a new infectious agent that had not yet been identified. Further research on the scrapie agent by Stanley Prusiner and others led to the identification of endogenous proteins called prions as the cause of these diseases.

"Unconventional viruses"

In his 1977 paper "Unconventional Viruses and the Origin and Disappearance of Kuru," Gajdusek postulated that the cause of kuru, scrapie and Creutzfeldt–Jakob disease were caused by what he termed an unconventional virus. In comparison to normal viruses, unconventional viruses had a long incubation period and did not cause an immune system response in the host. Although Gajdusek noted that there were no demonstrable nucleic acids in unconventional viruses, he did not rule out the possibility that unconventional viruses contained RNA in a smaller amount despite radiation resistance
These infectious agents were later discovered to be misfolded proteins, or prions.

Child molestation allegations and convictions

In the course of his research trips in the South Pacific, Gajdusek had brought 56 mostly male children back to live with him in the United States, and provided them with the opportunity to receive high school and college education. One of these boys, now a grown man, later accused Gajdusek of molesting him as a child.
Gajdusek was charged with child molestation in April 1996, based on incriminating entries in his personal diary and statements from a victim. He pleaded guilty in 1997 and, under a plea bargain, was sentenced to 12 months in jail. After his release in 1998, he was permitted to serve his five-year unsupervised probation in Europe. He never returned to the United States and lived in Amsterdam, spending winters in Tromsø, Norway, where the polar night around the winter solstice helped him to do more work.
Gajdusek's treatment was denounced in October 1996 as anti-elitist and unduly harsh by controversial former Edinburgh University psychologist Chris Brand.
The documentary The Genius and the Boys by Bosse Lindquist, first shown on BBC Four on June 1, 2009, notes that "seven men testified in confidentiality about Gajdusek having had sex with them when they were boys," that four said "the sex was untroubling" while for three of them "the sex was a shaming, abusive and a violation." One of these boys, the son of a friend and now an adult, appears in the film. Furthermore, Gajdusek openly admits to molesting boys and his approval of incest. The film tries to understand not only Gajdusek's sexual mores, but also his deeper motivations for science, exploration and life.

Death and legacy

Gajdusek died December 12, 2008, in Tromsø, Norway, at the age of 85. He was working and visiting colleagues in Tromsø at the time of his death.
Hanya Yanagihara's 2013 novel, The People in the Trees, is based on Gajdusek's life, research, and child molestation conviction. The novel centers on a character named A. Norton Perina, inspired by Gajdusek, whose research is conducted on the life-extending properties of turtle meat in Micronesia.

Works

Books

Daniel C. Gajdusek published hundreds of articles in scientific and medical journals. This is an incomplete list of some of the more cited ones.
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