Byrd played wide receiver for the South Carolina Gamecocks football team as a true freshman in 2011. After his senior season in 2014, Byrd had amassed 1265 yards on 68 receptions with 10 touchdowns. Byrd was considered the fastest player on the team while at South Carolina and also competed for the South Carolina track team.
Professional career
On the South Carolina Pro Day, Byrd only ran the 40-yard dash once, since his left calf muscle tightened up on him. Byrd, having a track & field background, was able to put up impressive numbers, completing the short shuttle in 4.03 seconds, the three-cone in 6.6 seconds and the 60-yard long shuttle in 10.90 seconds, faster than any other time posted at the 2015 scouting combine.
Carolina Panthers
On May 8, 2015, Byrd was signed as an undrafted free agent by the Carolina Panthers. On September 5, 2015, he was released by the Panthers. On September 7, 2015, Byrd was signed to the Panthers' practice squad, where he spent the rest of his rookie season. On February 7, 2016, Byrd's Panthers played in Super Bowl 50. In the game, the Panthers fell to the Denver Broncos by a score of 24–10.
2016
Byrd signed a reserve/futures contract with the Panthers on February 9, 2016. Byrd made the initial 53-man roster in 2016 but was inactive for the first five games before being released on October 14, 2016. He was re-signed to the practice squad the next day. He was promoted back to the active roster on December 29, 2016.
2017
On October 1, 2017 during the second quarter of a game versus the New England Patriots, Byrd broke his left arm on a reverse play. He was subsequently placed on the injured reserve two days later. He was activated off injured reserve to the active roster on December 2, 2017. In Week 16, Byrd returned a kickoff 103 yards, a franchise record, and scored the Panthers' first kickoff-return touchdown since 2011 which was crucial in the 22-19 win over the Buccaneers, earning him NFC Special TeamsPlayer of the Week. However during the second half of the game, Byrd suffered a lower leg injury and subsequently was placed on injured reserve on December 26, 2017.
2018
Byrd entered the 2018 season as the Panthers primary punt returner. He played in eight games before suffering a broken arm in Week 12. He was placed on injured reserve on November 27, 2018.
Arizona Cardinals
On March 26, 2019, Byrd signed with the Arizona Cardinals. He played in 11 games with three starts, recording a career-high 32 catches for 359 yards and one touchdown.
New England Patriots
On March 23, 2020, Byrd signed a one-year contract with the New England Patriots.
