DZME started its broadcast on June 15, 1968 when the Congress authorized Capitol Broadcasting Center of Jose M. Luison and Sons, Inc. to operate an AM radio station nationwide. During the first ten years of operations, the station operated on the frequency of 1540 kHz; until November 1978, when it was reassigned on the current frequency of 1530 kHz. However, in 1987, the then former president Corazon Aquino, through the National Telecommunications Commission, ordered to shut down DZME for a few months, which it was responsible for airing controversial right-wing propaganda and derogatory commentaries against the first Aquino Administration, during a series of coup attempts against the administration by the rebel soldiers, but it returned on the air thereafter in 1988. In 1996, a new group of investors including incumbent Surigao del Sur Congressman Prospero Pichay took over the assets and properties of the radio station, promising to continue the tradition of excellence in the new millennium. In 2004, DZME launched its new slogan: "Radyo Uno", coinciding with the acquisition of its brand new 25-kilowatt solid-state, digital AM stereo transmitter from Harris Electronics. In 2009, DZME transferred to its new home at the Victory Central Mall in Monumento, Caloocan City from its long-time former studios in Roosevelt Avenue, Quezon City as part of its plan to expand operations. Regional affiliates are likewise being developed to bolster its nationwide presence. Last November 14, 2013 to January 2014, some of the programs of DZME were temporarily postponed and replaced by music fillers due to technical maintenance/upgrades of the station & the transfer of the studios from Victory Central Mall in Monumento, Caloocan to OMM-Citra Building in Ortigas Center, Pasig City, in preparation of the station's major relaunch as well as launching of new programs. After Holy Week of 2015, the Radyo Uno brand was retired and became a news and music station. In the last quarter of 2016, DZME reverted as an all-news station by improving its overall programming line-up and revitalizing its news division, as well as the launch of its new programs, with a few of the station's old programs retained.
